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Related Concept Videos

Microbial Morphologies01:29

Microbial Morphologies

Bacterial and archaeal cells exhibit remarkable diversity in shape and structure, critical in their adaptability and functionality. Among bacteria, the most commonly observed shapes include cocci and bacilli. Cocci are spherical and may exist singly or in groupings such as pairs (diplococci), chains (streptococci), clusters (staphylococci), or tetrads. Bacilli, in contrast, are rod-shaped and can also occur as single cells, in pairs, or chains, depending on their environmental and genetic...

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Updated: Jul 1, 2026

Three-dimensional Biomimetic Technology: Novel Biorubber Creates Defined Micro- and Macro-scale Architectures in Collagen Hydrogels
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Engineered Living Structures with Shape-Morphing Capability Enabled by 4D Printing with Functional Bacteria.

Shan Liu1, Muxuan Yang1, Cade Smarr2

  • 1School of Polymer Science and Polymer Engineering, The University of Akron, Akron, Ohio 44325, United States.

ACS Applied Bio Materials
|April 22, 2024
PubMed
Summary
This summary is machine-generated.

Researchers created 3D-printed living structures using bacteria and hydrogels. These bifunctional materials produce cellulose nanofibers and exhibit shape-changing abilities, mimicking silkworms for advanced applications.

Keywords:
4D printingbacterial celluloseengineered living materialsmicrobial synthesisresponsive polymers

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Area of Science:

  • Biomaterials Engineering
  • Synthetic Biology
  • Materials Science

Background:

  • Engineered living structures with bacteria offer potential in biosensing, remediation, and medicine.
  • Achieving multifunctional capabilities (material production, shape transformation, sensing) in a single structure remains challenging.

Purpose of the Study:

  • To develop bifunctional living structures with material production and shape-morphing properties.
  • To integrate cellulose-generating bacteria with pH-responsive hydrogels using 3D printing.

Main Methods:

  • Utilized three-dimensional (3D) printing for precise fabrication of living structures.
  • Synergistically integrated cellulose-generating bacteria with pH-responsive hydrogels.
  • Investigated processing-structure-property relationships of the bifunctional materials.

Main Results:

  • Successfully fabricated 3D-printed bifunctional living structures.
  • Demonstrated cellulose nanofiber production under ambient conditions.
  • Achieved reversible and controlled shape-morphing properties (four-dimensional printing).

Conclusions:

  • The developed living structures exhibit biomimetic properties, similar to silkworms in nanofiber generation and motion.
  • On-demand separation of cellulose structures and bacterial viability after processing were confirmed.
  • These structures hold promise for advanced biomimetic applications.