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Testing for t(3;8) in MYC/BCL6-rearranged large B-cell lymphoma identifies a high-risk subgroup with inferior
Bernard D Maybury1, Lisa James2, Neil Phillips3
1Department of Haematology, University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom.
Abstract:
A reciprocal t(3;8) BCL6::MYC fusion is common in large B-cell lymphoma (LBCL) with MYC and BCL6 disruption. These pseudo-double-hit cases are not adverse, whereas t(3;8)-MYC/BCL6 lymphoma has an inferior prognosis relative to other MYC-rearranged LBCL.
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