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Updated: Jun 4, 2026

Intracortical Inhibition Within the Primary Motor Cortex Can Be Modulated by Changing the Focus of Attention
Published on: September 11, 2017
Out-of-phase transcranial alternating current stimulation modulates the neurodynamics of inhibitory control
Jeehye Seo1, Jehyeop Lee2, Byoung-Kyong Min3
1Institute of Brain and Cognitive Engineering, Korea University, Seoul 02841, Korea; BK21 Four Institute of Precision Public Health, Korea University, Seoul 02841, Korea.
Abstract:
Transcranial alternating current stimulation (tACS) is an efficient neuromodulation technique that enhances cognitive function in a non-invasive manner. Using functional magnetic resonance imaging, we investigated whether tACS with different phase lags (0° and 180°) between the dorsal anterior cingulate and left dorsolateral prefrontal cortices modulated inhibitory control performance during the Stroop task. We found out-of-phase tACS mediated improvements in task performance, which was neurodynamically reflected as putamen, dorsolateral prefrontal, and primary motor cortical activation as well as prefrontal-based top-down functional connectivity. Our observations uncover the neurophysiological bases of tACS-phase-dependent neuromodulation and provide a feasible non-invasive approach to effectively modulate inhibitory control.
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