Related Experiment Video
Updated: Jun 28, 2025
Laparoscopic Common Bile Duct Exploration in Patients with a Previous History of Biliary Tract Surgery
Published on: February 10, 2023
Higher Risk of Repeat Stone Surgery in Stone Formers With Concomitant Bowel Disease: Single-Center Long-Term Analysis
Margaret A Knoedler1, Shuang Li1, Shuhei Hirano1
1Department of Urology, University of Wisconsin School of Medicine and Public Health, Madison, WI.
Insights
Patients with bowel disease, particularly those with prior bowel resection or bypass, face a higher risk of repeat stone surgery. This risk was not elevated for inflammatory bowel disease or other bowel conditions.
Area of Science:
- Urology
- Gastroenterology
- Surgical Outcomes
Background:
- Bowel disease is a known risk factor for stone formation.
- The impact of different types of bowel disease on the need for repeat stone surgery is not well understood.
Purpose of the Study:
- To compare the risk of repeat stone surgery in patients with and without bowel disease.
- To investigate if different types of bowel disease influence the need for repeat stone surgery.
Main Methods:
- Retrospective analysis of surgical stone patients.
- Categorization of bowel disease into inflammatory bowel disease (IBD), bypass, resection, and other.
- Comparison of demographics, stone disease, and recurrent stone events using survival analyses.
Main Results:
- 24% of surgical stone patients had bowel disease.
- Patients with bowel disease were older and more likely female.
- Bowel resection and bypass were significantly associated with increased repeat stone surgery (P < .001 and P = .002).
- IBD and other bowel diseases did not show increased risk.
Conclusions:
- Patients with bowel disease, specifically prior bowel resection and bypass, have a higher risk of repeat stone surgery.
- The type of bowel disease is a critical factor in determining the risk of recurrent stone surgery.
Objective:
To identify the need for repeat stone surgery in patients with and without bowel disease. Few studies have compared risks between different types of bowel disease and whether their need for repeat stone surgery differs.
Methods:
From our IRB-approved study, we identified patients with and without bowel disease. We categorized patients' bowel disease into 4 categories: inflammatory bowel disease (IBD), bypass procedures, bowel resection, and bowel disease not otherwise specified (eg, irritable bowel syndrome, celiac disease). Differences between patient demographics, stone disease, and recurrent stone events for patients with and without bowel disease were compared using univariate and multivariate survival analyses (SPSS 25).
Results:
Of all surgical stone patients (2011), 484 (24%) had some type of bowel disease. Compared to patients without bowel disease, patients with bowel disease presented with stones at an older age (62.2 ± 14.5 vs 58.4 ± 15.3 years; P <.001) and were more likely to be female (56 vs 46%; P <.001). Patients with bowel disease required more repeat stone surgery than those without bowel disease (31% vs 23%, P <.001). In multivariate analysis, patients with bypass and bowel resection were associated with more repeat surgery than patients without bowel disease (P <.001, P = .002, respectively). Patients with IBD and bowel disease not otherwise specified did not have higher risk for repeat surgery than patients without bowel disease.
Conclusion:
Surgical stone patients with bowel disease, specifically those with prior bowel resection and bypass, had a higher risk of repeat stone surgery over time than stone formers without bowel disease.
Data Availability:
The data sets generated and analyzed during the current study are available from the corresponding author on reasonable request.
More Related Videos
Related Concept Videos
01:21Inflammatory Bowel Disease V: Surgical Management
Here are some common surgical interventions for IBD:
01:17Chronic Bowel Disorders: Introduction
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
01:30Inflammatory Bowel Disease II: Crohn's Disease
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
01:26Endoscopic Procedures IV: Sigmoidoscopy and Laproscopy
Sigmoidoscopy
Sigmoidoscopy is a diagnostic procedure that uses a flexible sigmoidoscope equipped with a light source and camera to examine the rectum and sigmoid colon. The procedure involves inserting the tube through the anus...
01:25Peptic Ulcer Disease V: Surgical Management and Nursing Care
Surgical Interventions for Peptic Ulcer Disease
01:27Inflammatory Bowel Disease I: Ulcerative Colitis
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...