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Insufficient sleep refers to not getting the recommended amount of sleep for optimal functioning, even if it's just slightly less than needed. Sleep insufficiency may occur due to lifestyle choices, such as staying up late for social events or work, resulting in routinely getting less sleep than required. For example, consistently sleeping 6 hours when the body needs 7-9 hours can lead to cumulative effects on health and well-being.
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Establishing a Device for Sleep Deprivation in Mice
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Chronic sleep deprivation impairs retinal circadian transcriptome and visual function.

Shenzhen Huang1, Wenxiao Zhang2, Shuting Xuan3

  • 1Henan Eye Institute, Henan Eye Hospital, Henan Provincial People's Hospital, People's Hospital of Henan University, People's Hospital of Zhengzhou University, Zhengzhou, China; Department of Ophthalmology, People's Hospital of Zhengzhou University, Henan Provincial People's Hospital, Zhengzhou, China.

Experimental Eye Research
|April 22, 2024
PubMed
Summary
This summary is machine-generated.

Chronic sleep deprivation (CSD) in mice significantly disrupts retinal circadian rhythms, altering gene expression, metabolism, and immune responses. This sleep loss impacts retinal structure and function, leading to decreased visual acuity.

Keywords:
Daily transcriptomic oscillationRNA sequencingReactive oxygen speciesRetinaSleep deprivation

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Area of Science:

  • Ophthalmology
  • Chronobiology
  • Neuroscience

Background:

  • Sleep loss is prevalent and linked to various eye diseases.
  • The specific impact of sleep deprivation on retinal structure, function, and circadian rhythms is not well understood.

Purpose of the Study:

  • To investigate the effects of chronic sleep deprivation (CSD) on the mouse retina.
  • To explore alterations in the retinal circadian system, gene expression, metabolism, immune response, and visual function.

Main Methods:

  • Utilized a chronic sleep deprivation (CSD) mouse model.
  • Analyzed retinal circadian transcriptome, metabolic and immune pathways, reactive oxygen species levels, ganglion cell complex thickness, microglial dynamics, and scotopic/photopic retinal function.

Main Results:

  • CSD significantly altered the retinal circadian transcriptome and enriched pathways.
  • Observed perturbations in metabolic and immune transcriptomes, increased reactive oxygen species, and altered ganglion cell complex thickness.
  • CSD induced diurnal shifts in microglial migration/morphology and markedly decreased both scotopic and photopic retinal function.

Conclusions:

  • Sleep deprivation broadly impacts retinal health by disrupting circadian gene expression, metabolism, immune response, and structural integrity.
  • Findings provide novel insights into the detrimental effects of sleep loss on the retina and visual function.