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Hepato-Cardio-Renal Syndrome
Abhilash Koratala1, Frederik Verbrugge2, Amir Kazory3
1Division of Nephrology, Medical College of Wisconsin, Milwaukee, WI.
Advances in Kidney Disease and Health
|April 22, 2024
Summary
Hepatorenal syndrome may involve heart dysfunction preceding kidney disease, suggesting a hepato-cardio-renal link. This challenges traditional views, highlighting the heart
Area of Science:
- Cardiology
- Hepatology
- Nephrology
Background:
- Hepatorenal syndrome (HRS) is a complex multisystem disorder linking cirrhosis to kidney dysfunction.
- Cardiac abnormalities are increasingly recognized in patients with advanced liver disease.
Purpose of the Study:
- To investigate the role of cardiac dysfunction in the development of kidney disease in patients with cirrhosis.
- To re-evaluate the pathophysiology of hepatorenal syndrome.
Main Methods:
- Review of recent advances in cardiac studies in patients with liver disease.
- Analysis of accumulating data on the temporal relationship between cardiac and kidney dysfunction.
Main Results:
- Subtle cardiac abnormalities are common in patients with advanced liver disease and cirrhosis.
- Cardiac dysfunction often precedes and predicts the development of kidney disease in these patients.
- These findings challenge the view that cardiac issues are merely a consequence of hepatorenal interactions.
Conclusions:
- The heart plays a key role in hepatorenal syndrome.
- Hepatorenal syndrome may represent a hepatic form of cardiorenal syndrome (hepato-cardio-renal syndrome).
- Liver disease can impact kidney function via cardiorenal pathways.
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