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Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
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Liver Disease-Associated Glomerulopathies

Swetha R Kanduri1, Yonatan Peleg2, Shikha Wadhwani2

  • 1Department of Nephrology, Ochsner Health System, New Orleans, LA; Ochsner Clinical School, The University of Queensland, New Orleans, LA.

Advances in Kidney Disease and Health
|April 22, 2024
PubMed

Insights

Hepatitis B (HBV) and C (HCV) viruses can cause kidney disease, including IgA nephropathy. Antiviral therapy is the primary treatment for HBV- and HCV-related glomerulonephritis, improving outcomes.

Area of Science:

  • Nephrology
  • Hepatology
  • Virology

Background:

  • Hepatitis B virus (HBV) and hepatitis C virus (HCV) cause global health issues.
  • Extra-hepatic manifestations, such as glomerular disease, are recognized complications.
  • Liver disease-associated IgA nephropathy is a leading cause of secondary IgA nephropathy.

Purpose of the Study:

  • To review epidemiology, pathogenesis, clinical features, and treatment of HBV- and HCV-related glomerulonephritis.
  • To discuss IgA nephropathy in patients with liver disease.
  • To provide an updated perspective on these kidney diseases.

Main Methods:

  • Literature review of HBV- and HCV-related glomerulonephritis.
  • Analysis of IgA nephropathy associated with liver disease.
  • Synthesis of current knowledge on pathogenesis and treatment.

Main Results:

  • Membranous nephropathy is common in HBV-related glomerulonephritis; others include MPGN and podocytopathies.
  • HCV-related glomerulonephritis often presents as cryoglobulinemic glomerulonephritis.
  • Antiviral therapy, especially direct-acting antivirals, has improved HBV-GN and HCV-GN outcomes.

Conclusions:

  • Antiviral therapy is the cornerstone for treating HBV- and HCV-related glomerulonephritis.
  • Immunosuppression (e.g., anti-CD20) may be used for severe or aggressive cases.
  • Understanding these viral-associated kidney diseases is crucial for patient management.

Keywords:
CryoglobulinemiaGlomerular diseasesHepatitis BHepatitis CMembranous nephropathySecondary IgA nephropathy

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