SlicerPIT: software development and implementation for planning and image-guided therapy in photoimmunotherapy
Takayoshi Suzuki1, Satoshi Kano2, Masanobu Suzuki1
1Department of Otolaryngology-Head and Neck Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Kita 15, Nishi 7, Kita-Ku, Sapporo, 060-8638, Japan.
International Journal of Clinical Oncology
|April 22, 2024
Summary
SlicerPIT software aids in precise planning for photoimmunotherapy, improving deep tumor treatment. This tool enhances surgical navigation for photoimmunotherapy, leading to better patient outcomes.
Area of Science:
- Oncology
- Medical Imaging
- Surgical Planning
Background:
- Photoimmunotherapy uses targeted drugs and infrared light for cancer cell death.
- Internal illumination for deep lesions requires precise placement of cylindrical diffusers via needle catheters.
- Accurate localization of deep tumors during surgery remains a challenge for optimal diffuser placement.
Purpose of the Study:
- To introduce SlicerPIT, a novel planning simulation software for photoimmunotherapy.
- To evaluate the utility of SlicerPIT in preoperative planning and surgical guidance for deep-seated tumors.
Main Methods:
- SlicerPIT enables 2D/3D placement of diffusers and illumination ranges on preoperative images.
- Planning data from SlicerPIT is exportable to image-guided surgical navigation systems.
- The software was utilized in seven photoimmunotherapy cycles across three patients with recurrent head and neck cancer.
Main Results:
- SlicerPIT facilitated preoperative planning and integration with navigation systems.
- Needle catheters were accurately punctured along the planned trajectory during surgery.
- Intraoperative imaging confirmed diffuser alignment, and postoperative scans showed complete tumor necrosis and shrinkage in all cases.
Conclusions:
- SlicerPIT supports detailed preoperative planning and accurate puncture for photoimmunotherapy.
- The software demonstrates potential to enhance treatment accuracy for deep lesions.
- SlicerPIT may improve patient outcomes in photoimmunotherapy for deep-seated cancers.
