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Related Concept Videos

Analgesia and Pain Management01:25

Analgesia and Pain Management

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Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
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Chemotherapy-Induced Nausea and Vomiting: Cannabinoids01:21

Chemotherapy-Induced Nausea and Vomiting: Cannabinoids

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Tetrahydrocannabinol (THC) is a phytocannabinoid that primarily interacts with the CB1 receptor, a type of G protein-coupled receptor (GPCR) predominantly in and around the chemoreceptor trigger zone (CTZ) and emetic center. THC also blocks the serotonin receptor activity in the dorsal vagal complex (DVC) by inhibiting serotonin release. THC exerts its anti-emetic effects through these interactions, which are beneficial for patients undergoing chemotherapy.
Two synthetic agonists of THC,...
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Opioid Analgesics: Synthetic and Semisynthetic Opioids01:15

Opioid Analgesics: Synthetic and Semisynthetic Opioids

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Synthetic and semisynthetic opioids are pivotal in pain management and tackling opioid addiction. Semisynthetic opioids, including morphinans (morphine derivatives), oxycodone, oxymorphone, hydrocodone, and hydromorphone, have improved pharmacokinetic profiles compared to morphine. Additionally, heroin and 6-MAM (6-Monoacetylmorphine) show better CNS penetration than morphine due to heightened lipid solubility. Hydromorphone, a potent opioid, undergoes hepatic metabolism to form the active...
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Local Anesthetics: Common Agents and Their Applications01:23

Local Anesthetics: Common Agents and Their Applications

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Local anesthetics (LAs) are commonly used for various applications in medical and dental procedures. Some of the common agents used are cocaine, lidocaine, and bupivacaine.
Cocaine is an ester of benzoic acid and methylecgogine. It is used to anesthetize and vasoconstrict locally. Currently, it is used primarily for topical applications. It is beneficial for surgeries on the upper respiratory tract, providing anesthesia and shrinking the mucosa. Cocaine in the form of cocaine hydrochloride is...
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Local Anesthetics: Chemistry and Structure-Activity Relationship01:27

Local Anesthetics: Chemistry and Structure-Activity Relationship

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Local anesthetics (LAs) are drugs that induce a temporary loss of sensation in a limited body area, preventing pain. Cocaine was the first local anesthetic discovered in the late 19th century. Cocaine is a benzoic acid ester obtained from the leaves of coca shrubs and was often used for its psychotropic effects. Cocaine was first isolated in 1860 by Albert Niemann. Sigmund Freud studied the physiological actions of cocaine. Carl Koller later introduced it into clinical practice in 1884 as a...
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Tooth Anatomy01:21

Tooth Anatomy

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The human tooth enables us to eat a variety of foods, speak clearly, and even aid in shaping our faces. Teeth are composed of various elements that work together. Here's a detailed look at the anatomy of a human tooth.
The Crown, Neck, and Root
The visible part of the tooth is referred to as the crown. It's covered by enamel, the hardest substance in the human body. The crown is uniquely shaped for each type of tooth, allowing for different functions such as cutting, tearing, or...
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Related Experiment Video

Updated: Jun 28, 2025

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Cannabidiol - an effective analgesic for toothache?

Siofra Murphy1, Ellis Hayes2

  • 1Department of Oral and Maxillofacial Surgery, University Hospital Crosshouse, Kilmarnock Rd, Crosshouse, Kilmarnock, KA2 0BE, Scotland. siofra.murphy2@ggc.scot.nhs.uk.

Evidence-Based Dentistry
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Cannabidiol (CBD) effectively reduced acute dental pain in a phase IIA trial. Epidiolex, a pure CBD solution, showed significant analgesia compared to placebo, with dose-dependent effects and manageable side effects.

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Area of Science:

  • Pharmacology
  • Clinical Trials
  • Pain Management

Background:

  • Investigates the efficacy and safety of Cannabidiol (CBD) as an analgesic for acute dental pain.
  • Utilizes Epidiolex, an FDA-approved, THC-free CBD oral solution, in a randomized, placebo-controlled, triple-arm, phase IIA clinical trial.
  • Includes 64 patients with moderate-to-severe odontogenic pain, randomly assigned to CBD10 (10 mg/kg), CBD20 (20 mg/kg), or placebo groups.

Discussion:

  • Both CBD doses demonstrated significant pain relief compared to baseline, with CBD20 showing a faster onset.
  • Pain reduction reached 50% at 60 minutes for CBD10 and 120 minutes for CBD20, with maximum reduction of 73% for both.
  • Increased bite force was observed in CBD groups, while sedation and gastrointestinal issues were more frequent with CBD administration.

Key Insights:

  • Pure CBD (Epidiolex) is an effective analgesic for acute dental pain.
  • Significant pain reduction was observed at 30 minutes for CBD10 and 15 minutes for CBD20.
  • Adverse events included increased sedation with CBD10 and gastrointestinal issues with CBD20.

Outlook:

  • Further research into optimal dosing and long-term effects of CBD for dental pain is warranted.
  • CBD presents a potential alternative analgesic option for managing acute dental pain.
  • The study highlights the therapeutic potential of non-psychoactive cannabinoids in pain management.