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Author Spotlight: Advancing Research on Candida albicans Biofilm-Associated Prosthetic Joint Infections
Published on: February 2, 2024
Outcomes in orthopedic device infections due to Streptococcus agalactiae: a retrospective cohort study
Ava Diarra1, Benoit Gachet1,2, Eric Beltrand3
1Department of Infectious Diseases, Hôpital Gustave Dron, 135 rue du Président Coty, F-59200, Tourcoing, France.
Background:
Group B streptococci (Streptococcus agalactiae) (GBS) is a rare cause of prosthetic joint infection (PJI) occurring in patients with comorbidities and seems to be associated with a poor outcome. Depiction of GBS PJI is scarce in the literature.
Methods:
A retrospective survey in 2 referral centers for bone joint infections was done Patients with a history of PJI associated with GBS between 2014 and 2019 were included. A descriptive analysis of treatment failure was done. Risk factors of treatment failure were assessed.
Results:
We included 61 patients. Among them, 41 had monomicrobial (67%) infections. The median duration of follow-up was 2 years (interquartile range 2.35) Hypertension, obesity, and diabetes mellitus were the most reported comorbidities (49%, 50%, and 36% respectively). Death was observed in 6 individuals (10%) during the initial management. The rate of success was 63% (26/41). Removal of the material was not associated with remission (p = 0.5). We did not find a specific antibiotic regimen associated with a better outcome.
Conclusion:
The results show that S. agalactiae PJIs are associated with high rates of comorbidities and a high treatment failure rate with no optimal treatment so far.
Insights
Group B Streptococcus (GBS) prosthetic joint infections (PJIs) are rare but linked to significant comorbidities and high treatment failure rates. Current treatments for GBS PJI lack a clear optimal strategy.
Area of Science:
- Infectious Diseases
- Orthopedic Surgery
- Microbiology
Background:
- Group B streptococci (GBS) are an uncommon cause of prosthetic joint infections (PJIs).
- GBS PJIs often affect patients with comorbidities and are associated with poor outcomes.
- Limited literature exists on GBS PJI management and outcomes.
Purpose of the Study:
- To investigate the characteristics, treatment outcomes, and risk factors for treatment failure in patients with GBS PJI.
- To analyze the success rates of different management strategies for GBS PJI.
Main Methods:
- Retrospective analysis of 61 patients with GBS PJI from two referral centers (2014-2019).
- Descriptive analysis of treatment failure and assessment of risk factors.
- Evaluation of comorbidities including hypertension, obesity, and diabetes.
Main Results:
- The majority of infections (67%) were monomicrobial.
- Common comorbidities included hypertension (49%), obesity (50%), and diabetes mellitus (36%).
- The overall treatment success rate was 63%, with 10% mortality during initial management. Material removal did not significantly impact remission.
Conclusions:
- S. agalactiae PJIs present with high comorbidity rates and a significant risk of treatment failure.
- No specific antibiotic regimen has been identified as superior for GBS PJI treatment.
- Further research is needed to establish optimal treatment protocols for GBS PJI.
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