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Related Concept Videos

mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

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The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
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Master Transcription Regulators02:23

Master Transcription Regulators

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Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a  complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
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Covalently Linked Protein Regulators02:04

Covalently Linked Protein Regulators

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Proteins can undergo many types of post-translational modifications, often in response to changes in their environment. These modifications play an important role in the function and stability of these proteins. Covalently linked molecules include functional groups, such as methyl, acetyl, and phosphate groups, and also small proteins, such as ubiquitin. There are around 200 different types of covalent regulators that have been identified.
These groups modify specific amino acids in a protein....
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Epigenetic Regulation01:37

Epigenetic Regulation

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Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
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Histone Modification02:32

Histone Modification

13.3K
The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone...
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PI3K/mTOR/AKT Signaling Pathway01:22

PI3K/mTOR/AKT Signaling Pathway

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The mammalian target of rapamycin  (mTOR) is a serine/threonine kinase that regulates growth, proliferation, and cell survival in response to hormones, growth factors, or nutrient availability. This kinase exists in two structurally and functionally distinct forms: mTOR complex 1  (mTORC1) and mTOR complex 2  (mTORC2). The first form (mTORC1) is composed of a rapamycin-sensitive Raptor and proline-rich Akt substrate, PRAS40. In contrast,  mTORC2 consists of a...
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  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. M1a Regulator-mediated Methylation Modification Patterns Correlated With Autophagy To Predict The Prognosis Of Hepatocellular Carcinoma.
  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. M1a Regulator-mediated Methylation Modification Patterns Correlated With Autophagy To Predict The Prognosis Of Hepatocellular Carcinoma.

Related Experiment Video

Global Level Quantification of Histone Post-Translational Modifications in a 3D Cell Culture Model of Hepatic Tissue
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Global Level Quantification of Histone Post-Translational Modifications in a 3D Cell Culture Model of Hepatic Tissue

Published on: May 5, 2022

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m1A regulator-mediated methylation modification patterns correlated with autophagy to predict the prognosis of hepatocellular carcinoma.

Yingmin Wu1,2,3,4, Lian Li5,6,7, Long Wang5,6,7

  • 1Department of Physiology, School of Basic Medical Sciences, Guizhou Medical University, 561113, Guiyang, China. wuyingmin1990@126.com.

BMC Cancer
|April 22, 2024

View abstract on PubMed

Summary
This summary is machine-generated.

N1-methyladenosine (m1A) RNA modifications are crucial in hepatocellular carcinoma (HCC). A new risk model identifies m1A regulators to predict HCC patient prognosis and suggests targeting m1A for cancer therapy.

Keywords:
AutophagyHepatocellular carcinoma (HCC)N1-methyladenosine (m1A)Prognosis

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Author Spotlight: Unveiling Transmembrane Protein Family-Related Markers in Gastric Cancer and Implications for Targeted Therapies
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Author Spotlight: Unveiling Transmembrane Protein Family-Related Markers in Gastric Cancer and Implications for Targeted Therapies

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Methyl-binding DNA capture Sequencing for Patient Tissues
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Methyl-binding DNA capture Sequencing for Patient Tissues

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Related Experiment Videos

Global Level Quantification of Histone Post-Translational Modifications in a 3D Cell Culture Model of Hepatic Tissue
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Global Level Quantification of Histone Post-Translational Modifications in a 3D Cell Culture Model of Hepatic Tissue

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Author Spotlight: Unveiling Transmembrane Protein Family-Related Markers in Gastric Cancer and Implications for Targeted Therapies
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Author Spotlight: Unveiling Transmembrane Protein Family-Related Markers in Gastric Cancer and Implications for Targeted Therapies

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Methyl-binding DNA capture Sequencing for Patient Tissues
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Methyl-binding DNA capture Sequencing for Patient Tissues

Published on: October 31, 2016

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Area of Science:

  • Oncology
  • Molecular Biology
  • Epigenetics

Background:

  • N1-methyladenosine (m1A) is a prevalent RNA modification implicated in cancer development.
  • Understanding m1A characteristics in hepatocellular carcinoma (HCC) is vital for identifying new therapeutic targets.

Purpose of the Study:

  • To systematically investigate m1A modification patterns in HCC.
  • To develop a predictive model for HCC patient prognosis based on m1A regulators.
  • To explore the role of m1A in HCC cell growth and autophagy.

Main Methods:

  • Integrated analysis of the TCGA-LIHC database for m1A regulators.
  • Construction of a risk model using differentially expressed genes (DEGs) linked to m1A patterns and autophagy.
m1A regulators
  • In vitro experiments and immunohistochemistry to validate findings in HCC tissues.

    • Main Results:

    • A five-gene risk model (CDK5R2, TRIM36, DCAF8L, CYP26B, PAGE1) demonstrated significant prognostic value for HCC.
    • HCC tissues exhibited lower m1A levels compared to paracancerous tissues.
    • Reduced m1A levels correlated with poorer clinical outcomes and may inhibit HCC proliferation via autophagy.

    Conclusions:

    • The developed risk model, incorporating m1A regulators and autophagy, can predict HCC prognosis.
    • Decreased m1A levels present a potential therapeutic target for anti-HCC strategies.