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Published on: February 17, 2018
Eligibility for knee arthroplasty is associated with increased risk of acquired hallux valgus - a Mendelian
Zhijun Li1, Zhengxuan Liu1, Wei Shi1
1Department of Orthopedics, Tianjin Medical University General Hospital, Tianjin, 300052, P. R. China.
Insights
Patients eligible for knee replacement surgery face a higher risk of developing hallux valgus. This study highlights the importance of monitoring hallux valgus in patients undergoing knee arthroplasty.
Area of Science:
- Orthopedics and Genetics
- Investigating the genetic links between osteoarthritis and hallux valgus.
Background:
- A high incidence of hallux valgus is observed in patients undergoing knee replacement.
- Osteoarthritis and hallux valgus are common conditions affecting the lower limbs.
Purpose of the Study:
- To determine if osteoarthritis patients undergoing surgery have an increased risk of hallux valgus.
- To analyze the causal relationship between knee replacement eligibility and hallux valgus using Mendelian randomization.
Main Methods:
- Utilized genomewide association study (GWAS) data for osteoarthritis and hallux valgus.
- Employed Mendelian randomization (MR) with inverse variance-weighted (IVW), weighted median, and MR-Egger methods.
- Assessed heterogeneity and pleiotropy using MR-Egger regression, MR-presso, and Cochran's Q tests.
Main Results:
- Mendelian randomization indicated a significantly higher risk of acquired hallux valgus in patients eligible for knee replacement surgery compared to controls.
- No significant causal relationships were identified for other analyzed conditions.
- All MR analyses demonstrated no significant heterogeneity or multiplicity.
Conclusions:
- The study provides evidence supporting an increased risk of acquired hallux valgus in individuals eligible for knee replacement.
- Clinicians should consider the hallux valgus status of patients scheduled for knee arthroplasty.
Objective:
Clinically, it has been found that patients undergoing knee replacement have a high incidence of concomitant hallux valgus. In this study, we analyzed whether patients with osteoarthritis who underwent surgery and those patient who did not have surgery had an increased risk of hallux valgus by Mendelian randomization and performed reverse causal analysis.
Design:
Genomewide association study (GWAS) data for osteoarthritis, categorized by knee arthritis with joint replacement, knee arthritis without joint replacement, hip arthritis with joint replacement, and hip arthritis without joint replacement.And acquired hallux valgus were downloaded for Mendelian randomized studies. MR analysis was performed using inverse variance-weighted (IVW), weighted median, and MR-Egger methods. MR-egger regression, MR pleiotropic residuals and outliers (MR-presso), and Cochran's Q statistical methods were used to evaluate heterogeneity and pleiotropy.
Results:
The IVW results indicate that, compared to healthy individuals, patients who meet the criteria for knee osteoarthritis joint replacement surgery have a significantly higher risk of acquired hallux valgus. There were no significant causal relationships found for the remaining results. No significant heterogeneity or multiplicity was observed in all the Mr analyses.
Conclusion:
Our study supports the increased risk of acquired hallux valgus in patients eligible for knee replacement. There is necessary for clinicians to be concerned about the hallux valgus status of patients undergoing knee arthroplasty.
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