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Adapted Resistance Training Improves Strength in Eight Weeks in Individuals with Multiple Sclerosis
Published on: January 29, 2016
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Multimodal exercise training to reduce frailty in people with multiple sclerosis: study protocol for a pilot
Tobia Zanotto1,2,3, Danya Pradeep Kumar4, Abbas Tabatabaei4
1Department of Occupational Therapy Education, School of Health Professions, University of Kansas Medical Center, Kansas City, KS, 66160, USA. tzanotto@kumc.edu.
Pilot and Feasibility Studies
|April 22, 2024
Summary
This pilot study investigates a multimodal exercise program to reduce frailty in people with multiple sclerosis (MS). The research will assess the program
Area of Science:
- Neurology
- Gerontology
- Rehabilitation Medicine
Background:
- Frailty is common in people with multiple sclerosis (pwMS), irrespective of age or disability.
- Frailty in MS is linked to negative outcomes like falls and worsening symptoms.
- Effective strategies are needed to reduce frailty in pwMS.
Purpose of the Study:
- To assess the feasibility of a multimodal exercise program for pwMS.
- To determine the preliminary efficacy of this program in reducing frailty.
- To provide novel data on exercise interventions for frailty in MS.
Main Methods:
- A pilot randomized controlled trial (RCT) involving 24 participants (aged 40-65) with MS and frailty.
- Participants were randomized to a 6-week multimodal exercise program (cognitive-motor rehabilitation + resistance training) or a waitlist control.
- Evaluations included the Evaluative Frailty Index for Physical Activity (EFIP), fall risk, quality of life, and biomarkers.
Main Results:
- Data on feasibility and preliminary efficacy of the multimodal exercise program will be collected.
- Changes in frailty, fall risk, and quality of life will be analyzed.
- Frailty-related biomarkers will be assessed post-intervention.
Conclusions:
- This study is the first RCT to evaluate targeted exercise for frailty in MS.
- Findings will offer insights into the potential of multimodal exercise to combat frailty in pwMS.
- The results will inform future, larger-scale interventions.
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