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Related Concept Videos

Magnetic Resonance Imaging01:24

Magnetic Resonance Imaging

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Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...
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Noninvasive Assessment of Cardiac Abnormalities in Experimental Autoimmune Myocarditis by Magnetic Resonance Microscopy Imaging in the Mouse
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In vivo diffusion MRI of the human heart using a 300 mT/m gradient system.

Maryam Afzali1,2, Lars Mueller1, Sam Coveney1

  • 1Biomedical Imaging Science Department, Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, UK.

Magnetic Resonance in Medicine
|April 23, 2024
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Summary

This study demonstrates cardiac diffusion-weighted MRI (DWI) using higher b-values and motion compensation on advanced scanners. Results show changes in mean diffusivity (MD) but not fractional anisotropy (FA) or angular metrics, paving the way for next-generation cardiac imaging.

Keywords:
cardiac diffusion MRIhigher‐order motion compensationstrong gradients

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Area of Science:

  • Cardiovascular Magnetic Resonance Imaging
  • Diffusion-Weighted Imaging (DWI)
  • Myocardial Microstructure Analysis

Background:

  • Cardiac diffusion-weighted imaging (DWI) is crucial for assessing myocardial microstructure.
  • Conventional DWI techniques are limited by lower b-values and motion artifacts.
  • High-performance gradient systems offer potential for advanced DWI applications.

Purpose of the Study:

  • To implement and evaluate cardiac DWI on a Connectom MR scanner with high-performance gradients (300 mT/m).
  • To investigate the benefits of increased gradient performance for myocardial microstructure assessment.
  • To explore the impact of higher b-values and advanced motion compensation on DWI metrics.

Main Methods:

  • Cardiac DWI performed on 10 healthy volunteers using a spin-echo sequence.
  • Employed second- and third-order motion compensation (M2 and M3) with b-values up to 1000 s/mm².
  • Calculated mean diffusivity (MD), fractional anisotropy (FA), helix angle (HA), and secondary eigenvector angle (E2A).

Main Results:

  • Third-order motion compensation (M3) resulted in slightly higher MD values compared to M2 (p < 0.0001).
  • Increasing maximum b-value from 450 to 1000 s/mm² significantly reduced MD (p < 1.6e-9 for M2, p < 1e-9 for M3).
  • No significant differences were observed in FA, HA, and E2A across different schemes (p > 0.05).

Conclusions:

  • Cardiac DWI is feasible in vivo with higher b-values and motion compensation than typically used.
  • Increased motion compensation order and b-value impact MD but not FA or angular metrics.
  • This approach enables advanced cardiac microstructure analysis on next-generation high-performance MR scanners.