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TBase - an Integrated Electronic Health Record and Research Database for Kidney Transplant Recipients
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Recurrent disease after pediatric renal transplantation

Anjali Nayak1, Robert Ettenger2, Katherine Wesseling-Perry1

  • 1Phoenix Children's Hospital and the University of Arizona College of Medicine, Tucson, Arizona, USA.

Pediatric Transplantation
|April 23, 2024
PubMed
Abstract

Insights

Recurrent kidney transplant diseases cause graft loss. New insights into pathophysiology and treatment are improving outcomes for conditions like primary hyperoxaluria and IgA nephropathy.

Area of Science:

  • Nephrology
  • Transplantation Immunology
  • Genitourinary Medicine

Background:

  • Recurrent diseases are a significant cause of kidney allograft failure, particularly in pediatric recipients.
  • Understanding the pathophysiology of these conditions is crucial for improving patient outcomes.
  • Recent scientific and therapeutic advancements offer new hope for managing post-transplant complications.

Purpose of the Study:

  • To review the current literature on recurrent diseases after kidney transplantation.
  • To discuss the diagnosis and management strategies for these conditions.
  • To highlight emerging insights into the pathophysiology and treatment of specific recurrent diseases.

Main Methods:

  • Comprehensive literature review of relevant studies.
  • Analysis of diagnostic criteria and management protocols.
  • Synthesis of recent findings on disease mechanisms and therapeutic interventions.

Main Results:

  • Recurrent diseases account for 7-8% of kidney allograft loss.
  • Diagnosis and management of recurrent diseases are complex and evolving.
  • New therapeutic approaches are showing promise in altering the course of several conditions.

Conclusions:

  • Advances in understanding pathophysiology and treatment are improving outcomes for post-transplant primary hyperoxaluria, focal segmental glomerulosclerosis, immune complex glomerulonephritis, C3 glomerulopathy, lupus nephritis, atypical hemolytic uremic syndrome, and IgA nephropathy.
  • Continued research is vital for further optimizing the care of kidney transplant recipients experiencing recurrent disease.
Keywords:
pediatric transplantationrecurrent disease

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