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An Ex vivo Culture System to Study Thyroid Development
Published on: June 6, 2014
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A case report of loss of thyroid transcription factor 1 expression in lung adenocarcinoma EBUS FNA
Hitesh Mathew1, Ros Bartle-Jones1
1Cytology Department, Royal Surrey NHS Foundation Trust, Guildford, UK.
Diagnostic Cytopathology
|April 23, 2024
Abstract:
We present a case report of a 76-year-old male with a histologically confirmed KRAS mutated, thyroid transcription factor 1 (TTF1) positive, grade 1, mucinous adenocarcinoma with cytologically difficult to interpret lymph node metastasis showing loss of TTF1 expression and overlapping features with goblet cell hyperplasia. The case highlights the importance of molecular testing in aiding diagnosis and guiding treatment of non-small cell lung carcinomas (NSCLC).

