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Updated: Jun 28, 2025
Comprehensive Echocardiographic Assessment of Right Ventricle Function in a Rat Model of Pulmonary Arterial Hypertension
Published on: January 20, 2023
Meta-analysis of the correlation between pulmonary hypertension and echocardiographic parameters in patients with
Jiahui Jin1,2, Wen Hao2, Deqiong Xie1,2
1School of Medicine and Life Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Insights
Pulmonary hypertension (PH) in chronic kidney disease (CKD) is linked to cardiac changes. Echocardiography reveals correlations between PH and parameters like left atrium size and ventricular function in CKD patients.
Area of Science:
- Cardiology
- Nephrology
- Medical Imaging
Background:
- Chronic kidney disease (CKD) is associated with increased cardiovascular complications.
- Pulmonary hypertension (PH) is a recognized complication in CKD patients, impacting prognosis.
- Echocardiography is a key non-invasive tool for assessing cardiac structure and function.
Purpose of the Study:
- To systematically investigate the correlation between echocardiographic parameters and pulmonary hypertension (PH) in patients with chronic kidney disease (CKD).
- To quantify the strength of association between various echocardiographic findings and the presence of PH in the CKD population.
Main Methods:
- A comprehensive systematic search of multiple databases (PubMed, Embase, Web of Science, etc.) was conducted up to May 19, 2023.
- Meta-analysis of 11 studies involving 1,809 CKD patients was performed using R language software.
- Study quality was assessed, and heterogeneity/sensitivity analyses were performed to ensure robustness of findings.
Main Results:
- Eleven studies including 1,809 CKD patients were analyzed.
- Ten echocardiographic parameters showed a positive correlation with CKD-PH, while FS and LVEF showed a negative correlation.
- Left atrium (LA) demonstrated a high correlation (0.70-0.89), followed by moderate correlations for LVDD, RA, RV, LVMI, and LVDS (0.40-0.69).
Conclusions:
- Patients with CKD and PH often exhibit enlarged cardiac chambers and thickened septal walls.
- Reduced pulmonary artery flow rates and impaired left ventricular function are characteristic of CKD-PH.
- Echocardiographic parameters provide valuable insights into the cardiac manifestations of PH in CKD.
Objective:
To investigate the correlation between pulmonary hypertension (PH) and echocardiographic parameters in patients with chronic kidney disease (CKD).
Methods:
PubMed, Embase, Web of Science, Cochrane, VIP, CNKI, and Wanfang databases were systematically searched for articles published from inception to 19 May 2023. Study quality was estimated using the Quality Assessment of Case-Control Studies tool. Forest plots were drawn using R language software. The "metacor" function in the "meta" package was utilized for meta-analysis of the r-values and their standard errors. Heterogeneity and sensitivity analyses were carried out, with the main outcomes as r-value, p-value, and I2 value.
Results:
Eleven studies were included, with 1,809 CKD patients. The correlations between 12 echocardiographic parameters and PH were analyzed. Except for FS and LVEF which were negatively correlated with CKD-PH, the other 10 parameters were positively correlated with CKD-PH. Among them, LA was highly correlated with CKD-PH (0.70 < r < 0.89); LVDD, RA, RV, LVMI, and LVDS were moderately correlated with CKD-PH (0.40 < r < 0.69); while PA, IVS, LVPW, SV, FS, and LVEF were lowly correlated with CKD-PH (0.20 < r < 0.39). The synthesized estimates were stable against heterogeneity.
Conclusion:
CKD-PH patients may have large cardiac chambers, thickened septal tissue on both sides of the chambers, reduced pulmonary artery flow rates, and decreased left ventricular function.
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