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Predicting central cervical lymph node metastasis in papillary thyroid carcinoma with Hashimoto's thyroiditis: a
Lirong Wang1, Lin Zhang1, Dan Wang1
1Department of Ultrasound, the Second Affiliated Hospital of Xi 'an Jiaotong University, Xi 'an, Shannxi, China.
Peerj
|April 23, 2024
Summary
This study identifies key factors like age and tumor size to predict central lymph node metastasis in papillary thyroid cancer patients with Hashimoto's thyroiditis, aiding surgical decisions.
Area of Science:
- Oncology
- Endocrinology
- Diagnostic Imaging
Background:
- Papillary thyroid carcinoma (PTC) with Hashimoto's thyroiditis (HT) often presents with enlarged central neck lymph nodes.
- These enlarged nodes can mimic metastatic lymph nodes, complicating surgical planning.
Purpose of the Study:
- To identify independent risk factors for central lymph node metastasis (CLNM) in PTC patients with HT.
- To develop and validate a predictive model (nomogram) for CLNM in this patient population.
Main Methods:
- Logistic regression analysis was used to determine risk factors.
- A nomogram was developed and validated using cross-validation, ROC curves, calibration curves, and decision curve analysis.
Main Results:
- Age, Tg-Ab level, tumor size, punctate echogenic foci, and blood flow grade were significant risk factors for CLNM.
- The predictive model achieved an AUC of 0.76, with 88% sensitivity and 51% specificity.
Conclusions:
- A clinic-ultrasound-based nomogram effectively predicts CLNM in HT PTC patients.
- This tool can assist clinicians in making informed decisions about surgical extent.
Keywords:
Central lymph node metastasisHashimoto’s ThyroiditisNomogramPapillary thyroid carcinomaUltrasound
