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Related Concept Videos

Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies01:28

Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies

115
Peptic ulcer disease (PUD) presents with diverse symptoms depending on the location and severity of the ulcer. Clinical manifestations of peptic ulcer include dull pain and a burning sensation in the mid-epigastric region.
Few clinical manifestations differentiate gastric ulcers from duodenal ulcers. Distinctions in the location, timing, and pain relief are crucial for healthcare providers in differentiating between gastric and duodenal ulcers during clinical assessments.
115
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  9. Predictive And Prognostic Markers
  11. Investigation Of Epstein-barr Virus, Cytomegalovirus, Human Herpesvirus 6, And Polyoma Viruses (jc Virus, Bk Virus) Among Gastric Cancer Patients: A Cross Sectional Study

Investigation of Epstein-Barr virus, Cytomegalovirus, Human herpesvirus 6, and Polyoma viruses (JC virus, BK virus) among Gastric cancer patients: A cross sectional study

Saber Soltani1,2, Abbas Farahani3,4, Ramin Shahbahrami1

  • 1Students' Scientific Research Center Tehran University of Medical Sciences Tehran Iran.

Health Science Reports
|April 23, 2024

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qPCR Is a Sensitive and Rapid Method for Detection of Cytomegaloviral DNA in Formalin-fixed, Paraffin-embedded Biopsy Tissue
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Isolation and Quantification of Epstein-Barr Virus from the P3HR1 Cell Line
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Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer
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Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer

Published on: September 18, 2020

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View abstract on PubMed

Summary
This summary is machine-generated.

This study investigated viral agents in gastric cancer, finding Epstein-Barr virus (EBV) in male samples and BK polyomavirus (BKV) in a female sample. Other tested viruses were not detected in the 60 gastric cancer specimens.

Area of Science:

  • Oncology
  • Virology
  • Molecular Biology

Background:

  • Gastric cancer presents a significant global health challenge with high mortality rates.
  • Several viral agents, including Epstein-Barr virus (EBV), cytomegalovirus (CMV), human herpesvirus 6 (HHV-6), John Cunningham virus (JCV), and BK polyomavirus (BKV), have been implicated in gastric malignancies.

Purpose of the Study:

  • To determine the frequency of EBV, CMV, HHV-6, JCV, and BKV in gastric cancer patients.
  • To evaluate the potential association of these viruses with gastric cancer.

Main Methods:

  • A cross-sectional study involving 60 gastric cancer specimens (32 male, 28 female).
  • DNA extraction from formalin-fixed paraffin-embedded tissues.
  • Polymerase chain reaction (PCR) was employed to detect the genomes of CMV, EBV, HHV-6, JCV, and BKV.
Keywords:
Epstein–Barr virusgastric cancerinfectionviruses

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Main Results:

  • Overall, 8.34% (5/60) of gastric cancer samples tested positive for viral agents.
  • Epstein-Barr virus (EBV) was detected in 6.67% (4/60) of male samples.
  • BK polyomavirus (BKV) was identified in 1.67% (1/60) of female samples. CMV, HHV-6, and JCV were not detected.

Conclusions:

  • The study identified the presence of EBV and BKV in gastric cancer specimens.
  • The genomes of CMV, HHV-6, and JCV were not found in the analyzed samples.
  • These findings suggest a potential role for EBV and BKV in gastric cancer, warranting further investigation.