Comparing cytocompatibility of two fluoride-containing solutions and two resin-based restorative materials-a pilot...

Area of Science:

• Biomaterials Science
• Dental Materials
• Cell Biology

Background:

• Cytocompatibility is crucial for dental materials, especially when soft tissue contact is possible.
• Understanding material interactions with oral mucosa is vital for patient safety.

Purpose of the Study:

• To compare the cytocompatibility of two fluoride-containing liquids (silver diamine fluoride, water-based silver fluoride) and two resin-containing restorative materials.
• To assess the materials' effects on buccal mucosa fibroblasts.

Main Methods:

• Buccal mucosa fibroblasts were exposed to four dental materials: silver diamine fluoride, water-based silver fluoride, Stela Light Cure, and Riva Light Cure.
• Cell viability was assessed at 24 and 48-hour intervals using statistical analysis (one-way ANOVA with Tukey's HSD).

Main Results:

• Most materials demonstrated significant cytocompatibility compared to controls at both 24 and 48 hours.
• Stela (SDI) showed a significant cytocompatibility result at 48h but not at 24h.
• No significant difference in cytocompatibility was found between the liquids and restorative materials at 24h, or among any of the four materials at 48h.

Conclusions:

• The direct method for Riva Star and Riva Star Aqua (step 1) is not viable.
• Stela Light Cure is a suitable material for soft tissue contact due to its cytocompatibility.
• Riva Star Aqua exhibits superior cytocompatibility compared to Riva Star.