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Potential role of the Eph/ephrin system in colorectal cancer: emerging druggable molecular targets

João Figueira Scarini1,2, Moisés Willian Aparecido Gonçalves1,2, Reydson Alcides de Lima-Souza1,2

  • 1Department of Pathology, Faculty of Medical Sciences, University of Campinas (UNICAMP), Campinas, São Paulo, Brazil.

Frontiers in Oncology
|April 23, 2024
PubMed

Insights

The Eph/ephrin system

Area of Science:

  • Molecular Biology
  • Oncology
  • Developmental Biology

Background:

  • The Eph/ephrin system is crucial for tissue regulation and development.
  • Its role in colorectal cancer (CRC) is complex, influencing tumorigenesis, angiogenesis, metastasis, and cancer stem cells.

Purpose of the Study:

  • To review the literature on the Eph/ephrin system in colorectal cancer.
  • To clarify the ambiguous roles of Eph receptors as oncogenes or tumor suppressors.
  • To identify promising molecular therapeutic targets within the Eph/ephrin pathway.

Main Methods:

  • Literature review of scientific publications.
  • Analysis of existing data on Eph/ephrin interactions in CRC.
  • Synthesis of molecular findings related to therapeutic potential.

Main Results:

  • Conflicting data exists regarding the oncogenic or tumor-suppressive roles of Eph receptors in CRC.
  • The Eph/ephrin system is implicated in key CRC processes like tumor growth and spread.
  • Specific molecular aspects of this system present potential therapeutic avenues.

Conclusions:

  • The precise role of Eph/ephrin signaling in colorectal cancer remains multifaceted and requires further elucidation.
  • Understanding these complex interactions is vital for developing targeted CRC therapies.
  • Molecular targets within the Eph/ephrin pathway offer promising strategies for future CRC treatment.
Keywords:
Eph/ephrin systemcolorectal cancer (CRC)malignant transformationneoangiogenesispathogenesistumor progression

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