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Updated: Jun 28, 2025

Author Spotlight: Decellularization-Based Quantification of Skeletal Muscle Fatty Infiltration
Published on: June 9, 2023
Relationship between Femur Mineral Content and Local Muscle Strength and Mass
Bruno V R Ramos1,2, Danilo A Massini1,2, Tiago A F Almeida1,2
1Graduate Programme in Human Development and Technology, São Paulo State University (UNESP), Rio Claro 13506-900, Brazil.
Muscle mass and strength are positively linked to femoral bone mineral content in young adult men. This highlights the importance of building muscle and strength for healthy bones during early adulthood.
Area of Science:
- Orthopedics
- Sports Medicine
- Human Physiology
Background:
- Exercise is crucial for bone health, providing mechanical stimulus and promoting lean tissue growth.
- Optimal timing for bone integrity interventions, considering age and sex differences, remains unclear.
- Understanding the relationship between body composition, muscle strength, and bone health in young adults is essential.
Purpose of the Study:
- To investigate the association between body composition, muscle strength, and femoral bone mineral content (BMC) in young adult males.
- To determine if lean tissue mass and muscle strength correlate with femoral BMC in this demographic.
Main Methods:
- Dual-energy X-ray absorptiometry (DXA) was used to assess body composition and bone density.
- One-repetition maximum (1-RM) tests were conducted to evaluate upper and lower limb muscle strength across various exercises.
- Pearson correlation coefficients were calculated to analyze relationships between variables.
Main Results:
- Lean tissue mass in the trunk, upper, and lower limbs showed significant positive correlations with femoral BMC (r = 0.55–0.72, p < 0.01).
- Muscle strength, assessed by 1-RM values, also correlated positively with femoral BMC (r = 0.34–0.46, p < 0.05).
Conclusions:
- Muscle mass and strength are positively associated with femoral bone mass in young adult men.
- Enhanced muscle mass and strength are important for maintaining femoral bone health in early adulthood.
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