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Cardiovascular MRI Reference Ranges for Heart, Aorta, and Pulmonary Artery in Healthy Chinese Children
Yukun Cao1, Hua Peng2, Kailu Zhang1
1Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Insights
Establishing cardiovascular magnetic resonance (CMR) reference ranges for Chinese children is crucial. This study provides age- and sex-specific CMR parameters for healthy Chinese children, aiding in accurate diagnosis and monitoring.
Area of Science:
- Pediatric Cardiology
- Medical Imaging
- Quantitative Cardiovascular Analysis
Background:
- Reference ranges for cardiovascular magnetic resonance (cardiac MR) parameters in Chinese children are currently unavailable.
- Establishing these ranges is essential for accurate interpretation of cardiac MR studies in this population.
Purpose of the Study:
- To establish age- and sex-specific reference ranges for cardiac MR parameters in a cohort of healthy Chinese children.
- To provide a normative dataset for the quantitative assessment of cardiac structure and function in pediatric populations.
Main Methods:
- A retrospective analysis was conducted on 196 healthy Chinese children (mean age 9.5 ± 3.6 years, 111 boys).
- Cardiac MR imaging was performed using a 1.5T scanner with balanced steady-state free precession sequences.
- Measurements included biventricular volumes and ejection fractions (EF), atrial volumes, left ventricular (LV) mass and thickness, and aortic root (AR) and main pulmonary artery (MPA) dimensions.
Main Results:
- Boys generally exhibited greater absolute measurements for LV volume, LA volume, RA area, LV thickness, AR, and MPA dimensions compared to girls.
- These sex-based differences were not significant when measurements were normalized to body surface area (BSA), except for RV volume and LV mass.
- Significant associations were found between age, BMI, and BSA with various cardiac parameters in both sexes.
Conclusions:
- This study successfully established 1.5T cardiac MR reference ranges for healthy Chinese children.
- These findings provide valuable normative data for the clinical evaluation of pediatric cardiovascular conditions in China.
Background:
Cardiovascular magnetic resonance (cardiac MR) reference ranges in Chinese children are lacking.
Purpose:
To establish age- and sex-specific reference ranges for cardiac MR parameters in a cohort of healthy Chinese children.
Study Type:
Retrospective.
Subjects:
One hundred ninety-six healthy children (mean age 9.5 ± 3.6 years, 111 boys).
Field Strength/Sequence:
1.5 T; balanced steady-state free precession.
Assessment:
Biventricular volume and ejection fractions (EF), left atrial (LA) volume, right atrial (RA) area, left ventricular (LV) mass and thickness, aortic root (AR), and main pulmonary artery (MPA) dimensions were measured. Parameters were compared between age groups and sex. The relationships between parameters and age, body mass index (BMI) and body surface area (BSA) were investigated.
Statistical Tests:
Independent-samples t tests; Pearson's correlation. A P value <0.05 was considered statistically significant.
Results:
Generally, boys exhibited greater absolute measurements of LV volume (end-diastolic: 94.4 ± 29.5 vs. 81.3 ± 31.0 mL), LA volume (end-diastolic: 42.6 ± 13.4 vs. 38.0 ± 13.3 mL), RA area (end-diastolic: 11.6 ± 2.5 vs. 10.8 ± 2.6 cm2), LV thickness (base: 4.4 ± 1.1 vs. 3.8 ± 0.9 mm), AR dimensions (annuls: 16.3 ± 2.7 vs. 15.0 ± 2.8 mm), and MPA dimensions (14.3 ± 2.3 vs. 13.1 ± 2.4 mm) than girls did. However, these differences were not observed when the measurements were normalized to BSA (LV volume: 75.3 ± 11.7 vs. 71.9 ± 12.3 mL/m2, P = 0.052; LA volume: 34.8 ± 8.9 vs. 34.5 ± 7.6 mL/m2, P = 0.783; RA area: 9.7 ± 2.3 vs. 10.2 ± 2.3 cm2/m2, P = 0.107; LV thickness: 3.6 ± 0.7 vs. 3.6 ± 0.9 mm/m2, P = 0.990; AR: 13.6 ± 2.7 vs. 14.3 ± 3.4 mm/m2, P = 0.108; MPA: 11.9 ± 2.3 vs. 12.4 ± 2.4 mm/m2, P = 0.118). Boys had greater RV volume (end-diastolic: 98.7 ± 33.5 vs. 82.7 ± 33.1 mL) and LV mass (52.6 ± 20.2 vs. 41.4 ± 16.0 g) compared to girls, irrespective of whether the values were indexed or not for BSA. Additionally, there were significant associations between age, BMI, and BSA with biventricular volume, LA volume, RA area, LV mass and thickness, AR and MPA dimensions in both boys and girls.
Data Conclusion:
This study suggests reference ranges at 1.5 T for Chinese children.
Evidence Level:
3 TECHNICAL EFFICACY: Stage 2.
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