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NK-like CD8 T cell: one potential evolutionary continuum between adaptive memory and innate immunity
Qiulei Wang1, Shaodan Chen1, Zhenhong Guo2
1Department of Immunology, School of Medicine, Jiangsu University, Zhenjiang, China.
Clinical and Experimental Immunology
|April 23, 2024
Summary
Certain CD8 T cells transform into NK-like cells, exhibiting innate-like functions. This review explores their differentiation, receptors, and roles in health and disease.
Area of Science:
- Immunology
- Cell Biology
Background:
- CD8 T cells are key adaptive immune cells for pathogen and abnormal cell defense.
- Aging, chronic infections, and autoimmune diseases increase differentiated memory CD8 T cells.
- Some memory CD8 T cells display innate-like cytotoxicity and natural killer (NK) cell receptors.
Purpose of the Study:
- To propose a differentiation model for NK-like CD8 T cells.
- To summarize the functions of NK-cell receptors on these cells.
- To offer new perspectives on their role in health and disease.
Main Methods:
- Literature review and analysis of existing studies.
- Examination of transcriptional profiles.
- Deduction of differentiation pathways.
Main Results:
- NK-like CD8 T cells possess transcriptional profiles of both CD8 T and NK cells.
- These cells suggest a potential CD8 T cell to NK cell transformation.
- Upregulation of NK-cell receptors indicates altered functional capabilities.
Conclusions:
- The induction mechanisms and implications of NK-like CD8 T cell transformation require further investigation.
- Understanding these cells offers novel insights into immune responses.
- This review provides a framework for future research on NK-like CD8 T cells in various conditions.
Keywords:
IL-15NK-like CD8 T cellinnate immunitykiller immunoglobulin-like receptorsmemory T cellnatural killerMore Related Videos
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