Related Experiment Video
Updated: Jun 28, 2025

High-throughput Quantitative Real-time RT-PCR Assay for Determining Expression Profiles of Types I and III Interferon Subtypes
Published on: March 24, 2015
Harnessing the power of IFN for therapeutic approaches to COVID-19
Elise G Viox1, Steven E Bosinger1,2,3, Daniel C Douek4
1Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, Georgia, USA.
Abstract:
Interferons (IFNs) are essential for defense against viral infections but also drive recruitment of inflammatory cells to sites of infection, a key feature of severe COVID-19. Here, we explore the complexity of the IFN response in COVID-19, examine the effects of manipulating IFN on SARS-CoV-2 viral replication and pathogenesis, and highlight pre-clinical and clinical studies evaluating the therapeutic efficacy of IFN in limiting COVID-19 severity.
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