Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A modified dexamethasone suppression test for endogenous depression.

R E Poland, R T Rubin, L A Lane

    Psychiatry Research
    |August 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Spectroscopic and theoretical investigation of the [Fe<sub>2</sub>(bdt)(CO)<sub>6</sub>] hydrogenase mimic and some catalyst intermediates.

    Physical chemistry chemical physics : PCCP·2019
    Same author

    Effect of pain neurophysiology education on physiotherapy students' understanding of chronic pain, clinical recommendations and attitudes towards people with chronic pain: a randomised controlled trial.

    Physiotherapy·2017
    Same author

    The intra- and inter-observer reliability of a novel protocol for two-point discrimination in individuals with chronic low back pain.

    Physiological measurement·2016
    Same author

    In Search of a Digital Toaster.

    American journal of audiology·2015
    Same author

    Coclear implants and the deaf culture.

    American journal of audiology·2015
    Same author

    Authors' reply to comment by Grant et al.

    European journal of pain (London, England)·2014
    Same journal

    Effect of Australian telepsychiatry services on attention-deficit hyperactivity disorder prescriptions.

    Psychiatry research·2026
    Same journal

    Cognitive correlates of Antisaccade Task performance in bipolar disorder.

    Psychiatry research·2026
    Same journal

    National estimates of exposure to potentially traumatic events among individuals with obsessive-compulsive disorder: Findings from The National OCD Survey.

    Psychiatry research·2026
    Same journal

    Digitally delivered cognitive bias modification for interpretation targeting hostile interpretation bias in compulsory drug rehabilitation: A feasibility randomized trial.

    Psychiatry research·2026
    Same journal

    Association of TyG-RFM with depressive symptoms: a nationally representative study enhanced by interpretable machine learning.

    Psychiatry research·2026
    Same journal

    Cross-national patterns of probable complex PTSD in post-communist Europe: A network analysis of five countries.

    Psychiatry research·2026
    See all related articles

    A simplified dexamethasone suppression test (DST) using a lower dose (0.5 mg) and single morning blood sample shows increased sensitivity for detecting central nervous system-pituitary-adrenal axis dysfunction in depression.

    Area of Science:

    • Endocrinology
    • Neuroscience
    • Psychiatry

    Background:

    • The standard dexamethasone suppression test (DST) is used to assess the central nervous system-pituitary-adrenal axis.
    • Simplifying the DST could improve its clinical utility.

    Purpose of the Study:

    • To simplify the dexamethasone suppression test (DST) by reducing the dexamethasone (DEX) dosage and shortening the sampling time.
    • To evaluate the sensitivity and specificity of a modified 0.5 mg DST compared to the standard 1.0 mg DST.

    Main Methods:

    • Normal volunteers received incremental DEX doses (0.125-1.0 mg) with single morning cortisol sampling.
    • Endogenously depressed patients and controls underwent both standard 1.0 mg DST and simplified 0.5 mg DST.
    • Cortisol levels were measured post-DEX to identify nonsuppressors.

    Related Experiment Videos

    Main Results:

    • The 0.5 mg DEX dose was the minimum to suppress cortisol in all normal subjects.
    • The simplified 0.5 mg DST identified more nonsuppressors in endogenously depressed patients (45%) compared to the standard 1.0 mg DST (20%).
    • Specificity of the 0.5 mg DST was comparable to the standard test.

    Conclusions:

    • The single-sample 0.5 mg DST is a more sensitive diagnostic tool than the standard 1.0 mg DST.
    • This simplified DST offers a potentially more effective method for evaluating the HPA axis in depression.
    • The modified test maintains comparable specificity to the conventional DST.