Related Experiment Video
Updated: Jun 28, 2025
09:52
Generation of High Quality Chromatin Immunoprecipitation DNA Template for High-throughput Sequencing ChIP-seq
Published on: April 19, 2013
24.4K
Time-to-Event Genome-Wide Association Study for Incident Cardiovascular Disease in People With Type 2 Diabetes
Soo Heon Kwak1,2,3, Ryan B Hernandez-Cancela4, Daniel A DiCorpo4
1Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea.
Diabetes Care
|April 23, 2024
Summary
Researchers identified new genetic risk factors for cardiovascular disease (CVD) in individuals with type 2 diabetes (T2D). This study advances understanding of genomic regions linked to CVD in this population.
Area of Science:
- Genetics
- Cardiovascular Medicine
- Endocrinology
Background:
- Type 2 diabetes (T2D) significantly increases the risk of cardiovascular disease (CVD).
- Identifying genetic factors influencing CVD risk in T2D populations is crucial for targeted prevention and treatment strategies.
Purpose of the Study:
- To discover novel genetic risk factors for incident CVD in individuals with T2D.
- To evaluate the association of known coronary artery disease (CAD) variants with incident CVD in the T2D cohort.
Main Methods:
- A multiancestry time-to-event genome-wide association study (GWAS) was performed on a large cohort of individuals with T2D.
- 204 established CAD variants were tested for association with incident CVD events within the T2D cohort.
Main Results:
- Three novel genetic loci (rs147138607, rs77142250, rs335407) were significantly associated with incident CVD in people with T2D.
- Five of the 204 tested known CAD variants showed significant association with incident CVD in this T2D cohort.
- A polygenic risk score comprising these variants was strongly associated with incident CVD (HR 1.14, P = 1.0 × 10-16).
Conclusions:
- The study highlights novel and previously identified genomic regions contributing to CVD risk in individuals with T2D.
- These findings provide a foundation for further research into the genetic architecture of CVD in T2D and potential clinical applications.
Related Concept Videos
01:11Genome-wide Association Studies-GWAS
13.4K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...
13.4K
01:36Carbohydrate Metabolism
11.1K
Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
11.1K
01:15Diabetes: Symptoms, Diagnosis, and Complications
526
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
526
01:23Assessment of the Cardiovascular System I: Subjective Data
322
A thorough health history and physical assessment are essential for identifying cardiovascular disease (CVD) symptoms and distinguishing them from other health issues.
Initial Enquiry
Ask the patient about their primary concern and thoroughly explore all reported symptoms.
Medical History
Investigate past illnesses affecting the cardiovascular system, such as angina, anemia, rheumatic fever, congenital heart disease, stroke, thrombophlebitis, dysrhythmias, varicosities
Inquire about symptoms...
Initial Enquiry
Ask the patient about their primary concern and thoroughly explore all reported symptoms.
Medical History
Investigate past illnesses affecting the cardiovascular system, such as angina, anemia, rheumatic fever, congenital heart disease, stroke, thrombophlebitis, dysrhythmias, varicosities
Inquire about symptoms...
322
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
81
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
81
01:20Pathophysiology of Diabetes
922
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
922