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Published on: August 16, 2018
New eremophilane-type sesquiterpenes from Synotis solidaginea
Xin-Yi Wei1, Hong-Bing Sun2, Rui-Ying Xi3
1Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu 610041, PR China; Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, PR China; University of Chinese Academy of Sciences, Beijing 101408, PR China.
Abstract:
Eleven new highly oxygenated eremophilane-type sesquiterpenoids were isolated from the whole plant of Synotis solidaginea, including two pairs of C-8 S/R epimers. The structures of the new compounds were elucidated on the basis of detailed spectroscopic analysis and the absolute configurations of 1 and 9 were confirmed by single-crystal X-ray crystallography using Cu Kα radiation. All the isolates were tested for the inhibition of LPS-stimulated NO production in macrophage-like mouse monocytic leukemia RAW264.7 cells. Compound 1 exhibited weak inhibitory effects with an IC50 of 71.2 μM.
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