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Updated: May 1, 2026

In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography
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Simultaneous Viability Assessment and Invasive Coronary Angiography Using a Therapeutic CT System in Chronic

Seongmin Ha1,2, Yeonggul Jang2,3, Byoung Kwon Lee4

  • 1Graduate Program of Biomedical Engineering, Yonsei University College of Medicine, Seoul, Korea.

Yonsei Medical Journal
|April 23, 2024
PubMed
Summary
This summary is machine-generated.

Delayed enhancement multi-detector computed tomography (DE-MDCT) is feasible for assessing myocardial viability in patients with myocardial infarction (MI). This technique correlates well with cardiac magnetic resonance (CMR) and offers high diagnostic accuracy without additional contrast agents.

Keywords:
Myocardial Infarctioncontrast mediacoronary angiographymultidetector computed tomographymyocardial stunning

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Area of Science:

  • Cardiovascular Imaging
  • Radiology
  • Medical Diagnostics

Background:

  • Myocardial infarction (MI) assessment requires accurate evaluation of myocardial viability.
  • Delayed enhancement imaging is crucial for characterizing scar tissue post-MI.
  • Current methods may involve additional contrast agents or separate procedures.

Purpose of the Study:

  • To evaluate the feasibility and diagnostic accuracy of delayed enhancement multi-detector computed tomography (DE-MDCT) for myocardial viability assessment.
  • To compare DE-MDCT with cardiac magnetic resonance (CMR) in patients with chronic MI.
  • To assess DE-MDCT performed concurrently with invasive coronary angiography (ICA) without additional contrast.

Main Methods:

  • Prospective enrollment of 13 patients with prior MI undergoing ICA.
  • Cardiac magnetic resonance (CMR) imaging performed before ICA.
  • Concurrent DE-MDCT viability scans performed during diagnostic ICA, without extra contrast.
  • Comparison of DE-MDCT scar volume and transmurality with DE-CMR.

Main Results:

  • Excellent correlation between DE-MDCT and DE-CMR for scar volume (r=0.986) and transmurality (r=0.900).
  • High diagnostic performance of DE-MDCT for differentiating viable from non-viable myocardium (accuracy 99.1%).
  • Sensitivity and specificity of 87.5% and 99.5%, respectively, using a 50% transmurality criterion.

Conclusions:

  • DE-MDCT is a feasible method for assessing myocardial viability in chronic MI patients.
  • Simultaneous acquisition with conventional ICA is possible without additional contrast.
  • DE-MDCT demonstrates high diagnostic accuracy compared to CMR.