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PPP2R1A silencing suppresses LUAD progression by sensitizing cells to nelfinavir-induced apoptosis and pyroptosis

Yating Liu1, Lianlian Ouyang1,2,3, Shiyao Jiang4,5

  • 1Department of Pharmacy, The Third Xiangya Hospital, Central South University, Changsha, 410013, Hunan, China.

Cancer Cell International
|April 23, 2024
PubMed

Insights

Meiotic genes, including PPP2R1A, are linked to lung adenocarcinoma (LUAD) progression and treatment response. Targeting these meiosis-related genes may offer new therapeutic strategies for LUAD patients.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Lung adenocarcinoma (LUAD) presents a significant public health challenge with a poor 5-year survival rate.
  • Aberrant alterations in meiotic genes are increasingly recognized for their potential role in cancer development.
  • A lack of comprehensive studies exists on the connection between meiotic genes and LUAD recurrence and treatment outcomes.

Purpose of the Study:

  • To investigate the prognostic value of meiotic genes in LUAD.
  • To identify specific meiotic genes that influence LUAD progression and treatment response.
  • To explore the therapeutic potential of targeting meiotic genes, specifically PPP2R1A, in LUAD.

Main Methods:

  • Utilized LASSO-Cox regression analysis to develop a meiosis-related prognostic model (MRPM) for LUAD.
  • Identified and analyzed the role of the gene PPP2R1A within the context of LUAD.
  • Investigated the effect of PPP2R1A repression on cellular apoptosis and pyroptosis in response to nelfinavir.

Main Results:

  • The developed MRPM demonstrated a strong correlation with LUAD progression.
  • PPP2R1A was identified as a key meiotic gene significantly contributing to LUAD processes.
  • Repressing PPP2R1A increased LUAD cell susceptibility to nelfinavir-induced apoptosis and pyroptosis.

Conclusions:

  • Meiosis-related genes, including PPP2R1A, are implicated in LUAD progression and may serve as prognostic markers.
  • Targeting meiosis-related genes presents a potential therapeutic avenue for LUAD.
  • These findings offer valuable insights for guiding clinical interventions in LUAD treatment.
Keywords:
Lung adenocarcinomaMeiotic genesNelfinavirPPP2R1APrognostic model

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