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Related Concept Videos

Embryonic Stem Cells00:57

Embryonic Stem Cells

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Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...
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Zygotic Development And Stem Cell Formation01:10

Zygotic Development And Stem Cell Formation

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The development of all multicellular organisms starts with the fusion of haploid cells called sperm and egg to form a diploid zygote. A zygote is a totipotent cell that can develop into a complete organism. The zygote undergoes cell division or cleavage to form an 8-cell mass. Until this stage, the cells are spherical, loosely attached, and remain totipotent. Totipotent cells are capable of developing both the embryonic and the extraembryonic tissues. However, as they continue to divide, they...
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Stem Cell Culture01:17

Stem Cell Culture

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Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
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Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

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Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
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Updated: Jun 28, 2025

Application of Mouse Parthenogenetic Haploid Embryonic Stem Cells as a Substitute of Sperm
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Application of Mouse Parthenogenetic Haploid Embryonic Stem Cells as a Substitute of Sperm

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Development and application of haploid embryonic stem cells.

Hai-Song Wang1, Xin-Rui Ma2, Yi-Hong Guo3

  • 1Center for Reproductive Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, No. 40 Daxue Road, 450052, Zhengzhou, Henan Province, China. hswang813@zzu.edu.cn.

Stem Cell Research & Therapy
|April 23, 2024
PubMed
Summary

Haploid embryonic stem cells offer unique advantages for genetic screening and targeted therapies because their single chromosome set directly reflects their genetic makeup. Establishing these cell lines is crucial for advancing research in development and medicine.

Keywords:
Gamete substitutionGenetic screeningHaploid diploidizationHaploid embryonic stem cellsX chromosome inactivation

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Development, Expansion, and In vivo Monitoring of Human NK Cells from Human Embryonic Stem Cells hESCs and Induced Pluripotent Stem Cells iPSCs
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Derivation of Hematopoietic Stem Cells from Murine Embryonic Stem Cells
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Derivation of Hematopoietic Stem Cells from Murine Embryonic Stem Cells

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Area of Science:

  • Developmental Biology
  • Stem Cell Research
  • Genetics

Background:

  • Haploid cells possess a single set of chromosomes, simplifying genotype-phenotype correlations.
  • Embryonic stem cells exhibit pluripotency, differentiating into various cell types.
  • Combining haploid and embryonic stem cell characteristics creates a powerful tool for biological research.

Purpose of the Study:

  • To review the progress in establishing and utilizing haploid embryonic stem cell lines.
  • To highlight the significance of haploid embryonic stem cells in various research fields.
  • To discuss the potential applications of these unique cells.

Main Methods:

  • This review synthesizes existing research on haploid embryonic stem cells.
  • It examines methodologies for their derivation and maintenance.
  • The paper discusses their utility in genetic screening and therapeutic development.

Main Results:

  • Haploid embryonic stem cells provide a simplified model for studying gene function.
  • Their direct genotype-phenotype link facilitates efficient genetic screening.
  • These cells show promise in drug discovery and targeted therapies.

Conclusions:

  • Establishing haploid embryonic stem cell lines is of significant importance.
  • These cells offer substantial advantages for research into developmental mechanisms, genetics, and personalized medicine.
  • Further research into haploid embryonic stem cells will likely accelerate breakthroughs in regenerative medicine and disease treatment.