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Associations between benign paroxysmal positional vertigo and seven mental disorders: a two-sample Mendelian
Shihan Liu1, Lingli Zhang2, Dan Deng3
1Department of Otorhinolaryngology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Frontiers in Neurology
|April 24, 2024
Summary
Benign paroxysmal positional vertigo (BPPV) shows no significant causal link with most mental disorders. However, neuroticism and mood swings may be identified as potential risk factors for BPPV.
Area of Science:
- Genetics
- Neurology
- Psychiatry
Background:
- The relationship between benign paroxysmal positional vertigo (BPPV) and mental health conditions remains debated.
- Investigating potential genetic links is crucial for understanding BPPV comorbidities.
Purpose of the Study:
- To clarify the potential causal associations between BPPV and seven common mental disorders using Mendelian randomization (MR).
- To explore BPPV complications and inform prevention and early treatment strategies for mental disorders.
Main Methods:
- Utilized two-sample Mendelian randomization (MR) analysis on genome-wide association study (GWAS) data for BPPV and seven mental disorders.
- Employed multiple MR methods including Inverse Variance Weighted (IVW), MR-Egger, and weighted median for robust analysis.
- Conducted reverse MR analysis to assess potential bidirectional relationships.
Main Results:
- MR analysis did not find significant causal associations between BPPV and bipolar disorder, depression, anxiety disorder, schizophrenia, or suicidality.
- A significant association was observed between neuroticism and BPPV (IVW: OR = 1.142, P = 0.001) and mood swings and BPPV (IVW: OR = 3.119, P = 0.0004).
- Post-adjustment analyses confirmed no significant pleiotropy or heterogeneity, supporting the association of neuroticism and mood swings with BPPV.
Conclusions:
- Benign paroxysmal positional vertigo (BPPV) does not appear to have a significant causal relationship with bipolar disorder, depression, anxiety disorder, schizophrenia, or suicidal tendencies.
- Neuroticism and mood swings may represent potential risk factors contributing to the development of BPPV.
- These findings contribute to understanding the complex interplay between BPPV and mental health.
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