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Chronic Obstructive Pulmonary Disease

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Generation of a Chronic Obstructive Pulmonary Disease Model in Mice by Repeated Ozone Exposure

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Chronic obstructive pulmonary disease (COPD) and COPD-like phenotypes.

Spyridon Fortis^1,2,3, Dimitris Georgopoulos³, Nikolaos Tzanakis³

¹Center for Access and Delivery Research and Evaluation, Iowa City VA Health Care System, Iowa City, IA, United States.

Frontiers in Medicine

|April 24, 2024

Summary

Chronic obstructive pulmonary disease (COPD) is complex. This review details COPD phenotypes for better prognostication and targeted treatments, including COPD-like conditions for future research.

Keywords:

chronic hypercapnic respiratory failure chronic hypoxemic respiratory failure chronic obstructive pulmonary disease frequent respiratory exacerbations hyperinflation phenotypes text word count: 2 preserved ratio impaired spirometry (PRISm)preserved spirometry at risk for COPD

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Area of Science:

Pulmonology
Respiratory Medicine
Clinical Phenotyping

Background:

Chronic obstructive pulmonary disease (COPD) is a heterogeneous respiratory condition.
Traditional phenotypes (chronic bronchitis, emphysema) lack granularity for specific treatments.
Current phenotypes inadequately capture COPD's complexity and heterogeneity.

Purpose of the Study:

To review COPD phenotypes offering prognostic value and guiding specific therapeutic interventions.
To explore COPD-like phenotypes for enhanced prognostication and potential future clinical trial targets.
To address the limitations of existing COPD classifications in reflecting disease heterogeneity.

Main Methods:

Literature review of COPD phenotypes.
Analysis of phenotypes for prognostic and treatment-indicating capabilities.
Identification and description of COPD-like phenotypes.

Main Results:

Several COPD phenotypes offer improved prognostication and treatment guidance beyond traditional classifications.
Inhaled glucocorticoids (ICS) may benefit specific chronic bronchitis phenotypes.
COPD-like phenotypes present opportunities for future research and targeted therapies.

Conclusions:

Advanced COPD phenotyping is crucial for personalized medicine in respiratory diseases.
Identifying specific phenotypes can optimize treatment strategies and improve patient outcomes.
COPD-like phenotypes warrant further investigation for novel therapeutic approaches.