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Updated: Jun 28, 2025

Establishment and Characterization of Three Afatinib-resistant Lung Adenocarcinoma PC-9 Cell Lines Developed with Increasing Doses of Afatinib

Establishment and Characterization of Three Afatinib-resistant Lung Adenocarcinoma PC-9 Cell Lines Developed with Increasing Doses of Afatinib

Published on: June 26, 2019

Bilateral keratitis associated with afatinib therapy.

Ya-Tung Liu¹, Chen-Wei Lin¹, Chi-Chin Sun^2,3

¹Department of Ophthalmology, Chang Gung Memorial Hospital, Chiayi, Taiwan.

Taiwan Journal of Ophthalmology

|April 24, 2024

Summary

Afatinib, an EGFR-TKI, may cause bilateral keratitis. Adjusting the afatinib dose and using eye drops can resolve this ocular side effect.

Keywords:

Afatinib epidermal growth factor receptor-tyrosine kinase inhibitor keratitis

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Published on: April 7, 2016

Area of Science:

Oncology
Ophthalmology
Pharmacology

Background:

Afatinib is an irreversible epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) used in cancer treatment.
Nasopharyngeal carcinoma (NPC) is a type of head and neck cancer.
Ocular side effects are potential complications of EGFR-TKI therapy.

Observation:

A 52-year-old male patient with stage IV NPC developed bilateral eye dryness and tenderness.
Symptoms worsened with increased afatinib dosage from 40 mg every other day to 40 mg daily.
Clinical examination revealed reduced visual acuity, punctate keratopathy, and a corneal epithelial defect.

Findings:

The patient's condition was diagnosed as bilateral keratitis potentially induced by afatinib.
Seidel tests were negative, and no signs of infection or other severe ocular complications were observed.
Reducing afatinib dosage and implementing intensive ocular hydration led to symptom resolution.

Implications:

This case highlights a potential link between afatinib and bilateral keratitis.
Early dose adjustment of afatinib and supportive ocular care can effectively manage this side effect.
Awareness among clinicians is crucial for prompt diagnosis and management of afatinib-induced ocular toxicity.