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Updated: Jun 28, 2025
07:30
Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study
Published on: August 18, 2020
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Cannabis use and mood disorders: a systematic review
Maryam Sorkhou1,2, Eliza L Dent3, Tony P George1,2
1Institute for Mental Health Policy and Research at CAMH, Toronto, ON, Canada.
Frontiers in Public Health
|April 24, 2024
Summary
Cannabis use is linked to a higher risk of developing major depressive disorder and bipolar disorder. It also worsens the prognosis for these mood disorders, highlighting potential negative impacts.
Area of Science:
- Psychiatry and Behavioral Science
- Neuroscience
- Public Health
Background:
- Problematic cannabis use is common in individuals with mood disorders.
- Understanding cannabis effects is crucial due to recreational legalization.
- Focus on major depressive disorder (MDD) and bipolar disorder (BD).
Approach:
- Systematic review of cross-sectional and longitudinal studies.
- Searched EMBASE, PsycINFO, PubMed, MEDLINE up to November 2023.
- Evaluated 3,262 studies, including 78 for analysis.
Key Points:
- Cannabis use associated with increased depressive and manic symptoms.
- Elevated likelihood of developing MDD and BD linked to cannabis use.
- Cannabis use correlates with poorer prognosis in MDD and BD.
Conclusions:
- Cannabis use may negatively impact the development and course of MDD and BD.
- Further research needed on cannabis type, amount, and frequency.
- Addressing confounding factors is essential for understanding the relationship.
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