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  11. Dpp3 Promotes Breast Cancer Tumorigenesis By Stabilizing Fasn And Promoting Lipid Synthesis

DPP3 promotes breast cancer tumorigenesis by stabilizing FASN and promoting lipid synthesis

Xiaoyu Fu1,2, Xu Li3, Weixing Wang2

  • 1Department of Breast and Thyroid Surgery, Renmin Hospital of Wuhan University, Wuhan 430060, China.

Acta Biochimica Et Biophysica Sinica
|April 24, 2024

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View abstract on PubMed

Summary
This summary is machine-generated.

Dipeptidyl peptidase 3 (DPP3) is elevated in breast cancer, promoting tumor growth and poor survival by altering fatty acid metabolism. Inhibiting DPP3 may offer a new therapeutic strategy.

Area of Science:

  • Oncology
  • Biochemistry
  • Molecular Biology

Background:

  • Dipeptidyl peptidase 3 (DPP3) is implicated in various pathophysiological processes and is upregulated in cancer.
  • The specific role and molecular mechanisms of DPP3 in breast cancer tumorigenesis and progression remain largely unknown.

Purpose of the Study:

  • To investigate the expression of DPP3 in breast cancer tissues.
  • To elucidate the biological functions and molecular mechanisms of DPP3 in breast cancer.
  • To evaluate the association between DPP3 expression and patient survival outcomes.

Main Methods:

  • Analysis of DPP3 expression in breast cancer tissues using The Cancer Genome Atlas (TCGA) database and clinical samples.
  • Kaplan-Meier survival analysis to assess the impact of DPP3 on survival.
Keywords:
breast cancerdipeptidyl peptidase 3fatty acid synthetase

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  • In vitro biochemical and cell biology assays, including DPP3 knockout cell lines, Gene Set Enrichment Analysis (GSEA), and metabolomic analysis.

    • Main Results:

    • DPP3 expression is significantly higher in breast cancer tissues compared to adjacent normal tissues.
    • High DPP3 expression correlates with poor survival outcomes in breast cancer patients.
    • DPP3 knockout inhibits tumor cell proliferation and migration while increasing apoptosis.
    • DPP3 influences lipid metabolism and fatty acid synthesis by stabilizing Fatty Acid Synthase (FASN) expression, leading to altered free fatty acid content.

    Conclusions:

    • DPP3 plays a crucial role in the reprogramming of fatty acid metabolism in breast tumors.
    • DPP3 is associated with poor prognosis in breast cancer patients.
    • DPP3 represents a potential novel therapeutic target for breast cancer treatment.