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Author Spotlight: Investigating Bacteriophage-Induced Immune Responses in Gnotobiotic Mice
Published on: January 26, 2024
[Experience with the use of bacteriophages in patients with neurogenic lower urinary tract dysfunction, complicated
V Zaitsev A1,2,3,4,5,6, A Lysachev D1,2,3,4,5,6, V Stroganov R1,2,3,4,5,6
1FGBOU VO Russian University of Medicine, Moscow, Russia.
Abstract:
Clinical cases of three patients with neurogenic lower urinary tract dysfunction, complicated by chronic urinary tract infection are presented in the article. All patients underwent clean intermittent catheterization and, in order to prevent symptomatic lower urinary tract infections, received bacteriophage therapy with a clinically proven positive effect. During 3 months follow-up, there were no episodes of urinary tract infection. A change in the concentration of uropathogens and restoration of sensitivity to a number of antimicrobial drugs were observed. Although phage therapy in urology requires further clinical research, it provides an additional strategy to treat urinary tract infections considering an increase in antibiotic resistance.
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