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Reference Value Fibrin Monomer in Healthy Children: A Cross-Sectional Study

Ta Anh Tuan1,2, Tran Dang Xoay1,2, Tran Thi Kieu My2

  • 1Pediatric Intensive Care Unit, Vietnam National Children's Hospital, Ha Noi, Vietnam.

Clinical and Applied Thrombosis/Hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
|April 24, 2024
PubMed

Insights

This study establishes fibrin monomer reference intervals for healthy Vietnamese children. These findings aid in diagnosing hypercoagulation and disseminated intravascular coagulation in pediatric patients.

Area of Science:

  • Pediatric Hematology
  • Clinical Chemistry

Background:

  • Establishing reference intervals for hemostasis markers is crucial for pediatric diagnostics.
  • Fibrin monomer levels can indicate hypercoagulation and disseminated intravascular coagulation (DIC).

Purpose of the Study:

  • To determine the reference intervals for fibrin monomer in a healthy Vietnamese pediatric population.
  • To provide essential data for the early diagnosis of coagulation disorders in children.

Main Methods:

  • A cross-sectional study involving 86 children undergoing elective orthopedic or inguinal hernia surgery.
  • Quantitative fibrin monomer testing using the STA-R system (Diagnostica Stago™).

Main Results:

  • The median fibrin monomer value was 2.56 µg/mL (IQR: 0.11-5.93).
  • No significant differences in fibrin monomer levels were observed across pediatric age groups (1 month to 18 years).

Conclusions:

  • This study presents the first fibrin monomer reference values for children in Vietnam.
  • These reference values can support the clinical diagnosis of hypercoagulation and DIC in pediatric patients.

Keywords:
DICchildrenfibrin monomerhealthyreference value

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