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MammalMethylClock R package: software for DNA methylation-based epigenetic clocks in mammals
Joseph Zoller1, Steve Horvath1,2,3
1Department of Biostatistics, Fielding School of Public Health, University of California, Los Angeles, CA, 90095, United States.
Motivation:
Epigenetic clocks are prediction methods based on DNA methylation levels in a given species or set of species. Defined as multivariate regression models, these DNA methylation-based biomarkers of age or mortality risk are useful in species conservation efforts and in preclinical studies.
Results:
We present an R package called MammalMethylClock for the construction, assessment, and application of epigenetic clocks in different mammalian species. The R package includes the utility for implementing pre-existing mammalian clocks from the Mammalian Methylation Consortium.
Availability And Implementation:
The source code and documentation manual for MammalMethylClock, and clock coefficient .csv files that are included within this software package, can be found on Zenodo at https://doi.org/10.5281/zenodo.10971037.
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