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Skin Diseases and Disorders

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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
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Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
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Psychoneuroimmunology: Cardiovascular Disease01:27

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Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
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Chronic Bowel Disorders: Introduction01:17

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Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
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Updated: Jun 28, 2025

Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients
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Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients

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Psoriasis as a Systemic Disease.

Ulrich Mrowietz1, Felix Lauffer, Wiebke Sondermann

  • 1Psoriasis Centre at the Department of Dermatology, Department of Dermatology, University Medical Center Schleswig-Holstein, Campus Kiel; Department of Dermatology and Allergology, Biederstein, Technical University of Munich; Department of Dermatology, Venereology, Allergology, University Hospital Essen, University Duisburg-Essen, Essen; Rheumatology center of the Ruhr area, Ruhr-University Bochum, Herne.

Deutsches Arzteblatt International
|April 24, 2024
PubMed
Summary
This summary is machine-generated.

Psoriatic disease is a systemic inflammatory condition affecting skin, joints, and arteries, not just the skin. Management requires a collaborative approach between physicians and patients for optimal treatment strategies.

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Area of Science:

  • Dermatology
  • Rheumatology
  • Cardiology
  • Immunology

Background:

  • Psoriasis, once considered a skin-only inflammatory condition, is now recognized as a systemic disease termed psoriatic disease.
  • Emerging data from multiple research fields confirm its systemic nature.

Purpose of the Study:

  • To provide a comprehensive overview of psoriatic disease.
  • To highlight its systemic manifestations and associated conditions.
  • To discuss current understanding of its pathogenesis and treatment.

Main Methods:

  • Selective literature review focusing on clinical trials and current publications.
  • Inclusion of international guideline recommendations.

Main Results:

  • Psoriatic disease involves immunologically mediated inflammation of skin, arteries, bones, and joints.
  • Associated conditions include hypertension, metabolic syndrome, and depression.
  • Obesity is a primary risk factor, while stress and infection are common triggers.
  • Complex genetics and specific cytokine involvement (IL-17, IL-23) characterize its inflammatory pattern.
  • Modern biologic and other therapies can target underlying inflammatory processes.

Conclusions:

  • Psoriatic disease is a complex systemic condition requiring structured management.
  • Physician-patient collaboration is essential for developing optimal treatment strategies.