Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

REM Sleep Behavior Disorder01:15

REM Sleep Behavior Disorder

182
REM Sleep Behavior Disorder (RBD) is a sleep disorder characterized by the absence of muscle paralysis that normally occurs during the REM phase of sleep. This absence allows individuals to physically act out their dreams, which are often vivid and disturbing. Common behaviors exhibited during episodes include kicking, punching, and yelling. These actions can be dangerous, potentially leading to injuries for the person with RBD or their bed partner.
RBD is significantly associated with...
182
Neural Regulation01:37

Neural Regulation

39.4K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
39.4K
Parkinson's Disease: Overview01:15

Parkinson's Disease: Overview

537
Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
537

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Telomeres, REM sleep, and RBD: A link to neurodegeneration?

Parkinsonism & related disorders·2025
Same author

Possible REM behavior disorder following use of passionflower.

Sleep medicine·2025
Same author

Periodic limb movements in REM sleep: A periodically concerning phenomenon.

Sleep medicine·2025
Same author

Trauma-Associated Sleep Disorder.

Sleep medicine clinics·2024
Same author

Headache improves with armodafinil.

Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine·2023
Same author

Neurologic and psychiatric features of impending neurodegeneration in iRBD.

Clinical parkinsonism & related disorders·2023
Same journal

Association of media use with sleep of children and adolescents: an umbrella review.

Sleep medicine reviews·2026
Same journal

Beyond respiratory control in COMISA: Towards precision phenotyping in PAP-based therapies.

Sleep medicine reviews·2026
Same journal

The potential of clustering methods for pre-test triage in sleep medicine: A systematic review.

Sleep medicine reviews·2026
Same journal

Assessing the effects of non-invasive transcranial electrical stimulation (tACS and tDCS) on electrophysiological sleep parameters - a systematic review.

Sleep medicine reviews·2026
Same journal

Thirty-five years of the Pittsburgh sleep quality index: a critical appraisal and a path forward for its contemporary use.

Sleep medicine reviews·2026
Same journal

What do we know about the Epworth Sleepiness Scale in women? A review of the evidence.

Sleep medicine reviews·2026
See all related articles

Related Experiment Video

Updated: Jun 28, 2025

An Alternative Approach to Study Primary Events in Neurodegeneration Using Ex Vivo Rat Brain Slices
07:57

An Alternative Approach to Study Primary Events in Neurodegeneration Using Ex Vivo Rat Brain Slices

Published on: April 11, 2018

6.9K

Secondary RBD: Not just neurodegeneration.

Daniel A Barone1

  • 1Weill Cornell Center for Sleep Medicine, 425 East 61st Street, New York, NY, 10065, USA.

Sleep Medicine Reviews
|April 24, 2024
PubMed
Summary
This summary is machine-generated.

Rapid eye movement sleep behavior disorder involves acting out dreams, often linked to neurodegenerative diseases. This study focuses on cases without such underlying conditions, exploring secondary causes.

Keywords:
NeurodegenerationParasomniaRBDSynucleinopathy

More Related Videos

Using Retinal Imaging to Study Dementia
09:17

Using Retinal Imaging to Study Dementia

Published on: November 6, 2017

21.6K
Motor and Hippocampal Dependent Spatial Learning and Reference Memory Assessment in a Transgenic Rat Model of Alzheimer's Disease with Stroke
09:45

Motor and Hippocampal Dependent Spatial Learning and Reference Memory Assessment in a Transgenic Rat Model of Alzheimer's Disease with Stroke

Published on: March 22, 2016

10.2K

Related Experiment Videos

Last Updated: Jun 28, 2025

An Alternative Approach to Study Primary Events in Neurodegeneration Using Ex Vivo Rat Brain Slices
07:57

An Alternative Approach to Study Primary Events in Neurodegeneration Using Ex Vivo Rat Brain Slices

Published on: April 11, 2018

6.9K
Using Retinal Imaging to Study Dementia
09:17

Using Retinal Imaging to Study Dementia

Published on: November 6, 2017

21.6K
Motor and Hippocampal Dependent Spatial Learning and Reference Memory Assessment in a Transgenic Rat Model of Alzheimer's Disease with Stroke
09:45

Motor and Hippocampal Dependent Spatial Learning and Reference Memory Assessment in a Transgenic Rat Model of Alzheimer's Disease with Stroke

Published on: March 22, 2016

10.2K

Area of Science:

  • Neurology
  • Sleep Medicine
  • Parasomnias

Background:

  • Rapid eye movement sleep behavior disorder (RBD) is a parasomnia marked by dream enactment and loss of muscle atonia during REM sleep.
  • Isolated RBD is more common in older males and associated with synucleinopathies like Parkinson's disease.
  • Secondary RBD arises from other conditions or substances, with neurodegenerative diseases being the most frequent cause.

Purpose of the Study:

  • To investigate the specific subset of secondary rapid eye movement sleep behavior disorder (RBD) that occurs in the absence of neurodegenerative diseases.
  • To differentiate non-neurodegenerative causes of RBD from those linked to synucleinopathies.

Main Methods:

  • Review of existing literature on secondary RBD.
  • Analysis of case studies focusing on non-neurodegenerative etiologies.
  • Differential diagnosis of RBD subtypes.

Main Results:

  • Identified various non-neurodegenerative conditions and substances associated with secondary RBD.
  • Highlighted the importance of a thorough medical history to identify potential triggers.
  • Demonstrated that RBD can manifest without underlying synucleinopathies.

Conclusions:

  • Secondary RBD without neurodegenerative disease is a distinct clinical entity.
  • Accurate diagnosis requires careful consideration of all potential contributing factors beyond synucleinopathies.
  • Further research is needed to fully understand the mechanisms and management of non-neurodegenerative secondary RBD.