Localized colorectal cancer database integrating 4 randomized controlled trials; (JCOG2310A).

Area of Science:

• Oncology
• Clinical Trials
• Biostatistics

Background:

• Phase III randomized controlled trials (RCTs) are statistically robust but costly.
• Limited integrated databases hinder ancillary and supplementary analyses of RCTs.
• The Colorectal Cancer Study Group (CCSG) of the Japan Clinical Oncology Group (JCOG) addressed this limitation.

Purpose of the Study:

• To establish an integrated database of ancillary studies from four phase III RCTs (JCOG0212, JCOG0404, JCOG0910, JCOG1006).
• To investigate specific clinicopathological factors in pStage II/III colorectal cancer (JCOG2310A).
• To facilitate future analyses relevant to localized colorectal cancer management.

Main Methods:

• Integration of data from four completed phase III colorectal cancer RCTs.
• Establishment of a centralized database for ancillary studies.
• Planned updates to include additional clinical trial data.

Main Results:

• A comprehensive database (JCOG2310A) has been successfully established by the CCSG.
• The database integrates data from four key JCOG phase III colorectal cancer trials.
• This initiative enables detailed investigation of clinicopathological factors.

Conclusions:

• The JCOG2310A database provides a valuable resource for colorectal cancer research.
• It will support ongoing and future analyses for localized disease management.
• This initiative by JCOG cOlorectal Young investigators (JOY) enhances the utility of existing RCTs.