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Updated: Jun 28, 2025
10:36
Systems Biology of Metabolic Regulation by Estrogen Receptor Signaling in Breast Cancer
Published on: March 17, 2016
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Estrogen receptor beta expression and role in cancers
Fátima L Monteiro1, Lina Stepanauskaite1, Amena Archer1
1SciLifeLab, Department of Protein Science, KTH Royal Institute of Technology, Solna 171 21, Sweden; Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge 141 83, Sweden.
The Journal of Steroid Biochemistry and Molecular Biology
|April 24, 2024
Summary
Estrogen receptor beta (ERβ) expression in various cancers is debated, often due to unreliable antibody assays. This review focuses on ERβ
Area of Science:
- Oncology
- Endocrinology
- Molecular Biology
Background:
- Estrogen receptor alpha (ERα) drives some cancers, like breast cancer.
- Estrogen receptor beta (ERβ) is also activated by estrogen, but its role and expression in various cancers are debated.
- Nonspecific antibody use has led to confusion regarding ERβ's function in cancer.
Purpose of the Study:
- To review the controversial role of ERβ in cancer.
- To focus on tumor expression of ERβ supported by non-antibody-dependent assays.
- To explore ERβ's potential role in specific cancers like lymphoma and granulosa cell tumors.
Main Methods:
- Review of existing literature on ERβ expression in cancer.
- Analysis of transcript-level expression data for ERβ.
- Focus on non-antibody-dependent assays to validate ERβ expression.
- Examination of ERβ's role in lymphoma, granulosa cell tumors, testicular, and adrenal cancers.
Main Results:
- ERβ expression is complex and debated across different cancer types.
- Non-antibody-dependent assays provide more reliable evidence of ERβ tumor expression.
- ERβ may play a role in specific cancers, including lymphoma and granulosa cell tumors.
- Transcript-level data suggests variable ERβ expression in certain malignancies.
Conclusions:
- Further research is needed to clarify ERβ's complex role in cancer.
- Reliable assays are crucial for accurate assessment of ERβ expression and function.
- ERβ's involvement in specific cancers warrants deeper investigation.
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