Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Telomeres and Telomerase02:41

Telomeres and Telomerase

23.3K
In eukaryotic DNA replication, a single-stranded DNA fragment remains at the end of a chromosome after the removal of the final primer. This section of DNA cannot be replicated in the same manner as the rest of the strand because there is no 3’ end to which the newly synthesized DNA can attach. This non-replicated fragment results in gradual loss of the chromosomal DNA during each cell duplication. Additionally, it can induce a DNA damage response by enzymes that recognize single-stranded...
23.3K
Replicative Cell Senescence02:15

Replicative Cell Senescence

3.6K
Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds...
3.6K
Replication in Eukaryotes01:29

Replication in Eukaryotes

13.7K
In eukaryotic cells, DNA replication is highly conserved and tightly regulated. Multiple linear chromosomes must be duplicated with high fidelity before cell division, so there are many proteins that fulfill specialized roles in the replication process. Replication occurs in three phases: initiation, elongation, and termination, and ends with two complete sets of chromosomes in the nucleus.
Many Proteins Orchestrate Replication at the Origin
Eukaryotic replication follows many of the same...
13.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Infections and severe mental illness: a population-based matched cohort study.

BMJ mental health·2026
Same author

Trends and inequalities in statin use for the primary and secondary prevention of cardiovascular disease between 2009 and 2021 in England: a series of cross-sectional and cohort studies.

BMJ public health·2026
Same author

Artificial intelligence to improve the detection and risk stratification of acute pulmonary embolism (AID-PE): protocol for a pragmatic quasi-experimental comparator study.

BMJ open·2026
Same author

Incidence and prevalence of obstructive sleep apnoea and narcolepsy in the UK: a population-based descriptive study.

Thorax·2026
Same author

Mental health symptoms as preclinical indicators of dementia: a Whitehall II cohort study.

medRxiv : the preprint server for health sciences·2026
Same author

Public Health.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2025

Related Experiment Video

Updated: Jun 28, 2025

Author Spotlight: Exploring the Impact of Trauma on Cellular Aging
11:44

Author Spotlight: Exploring the Impact of Trauma on Cellular Aging

Published on: March 22, 2024

1.7K

Infection and telomere length: a systematic review protocol.

Louis Tunnicliffe1, Rutendo Muzambi2,3, Jonathan W Bartlett2

  • 1Faculty of Epidemiology & Population Health, London School of Hygiene & Tropical Medicine, London, UK louis.tunnicliffe@lshtm.ac.uk.

BMJ Open
|April 24, 2024
PubMed
Summary

This study synthesizes evidence on infections and telomere shortening, a marker of cellular aging. It aims to clarify the association across diverse infections and populations to guide future research on aging and disease.

Keywords:
AgingINFECTIOUS DISEASESNEUROLOGY

More Related Videos

Author Spotlight: Optimization of Performance Parameters of the TAGGG Telomere Length Assay
08:23

Author Spotlight: Optimization of Performance Parameters of the TAGGG Telomere Length Assay

Published on: April 21, 2023

2.9K
Modified Terminal Restriction Fragment Analysis for Quantifying Telomere Length Using In-gel Hybridization
11:29

Modified Terminal Restriction Fragment Analysis for Quantifying Telomere Length Using In-gel Hybridization

Published on: July 10, 2017

12.9K

Related Experiment Videos

Last Updated: Jun 28, 2025

Author Spotlight: Exploring the Impact of Trauma on Cellular Aging
11:44

Author Spotlight: Exploring the Impact of Trauma on Cellular Aging

Published on: March 22, 2024

1.7K
Author Spotlight: Optimization of Performance Parameters of the TAGGG Telomere Length Assay
08:23

Author Spotlight: Optimization of Performance Parameters of the TAGGG Telomere Length Assay

Published on: April 21, 2023

2.9K
Modified Terminal Restriction Fragment Analysis for Quantifying Telomere Length Using In-gel Hybridization
11:29

Modified Terminal Restriction Fragment Analysis for Quantifying Telomere Length Using In-gel Hybridization

Published on: July 10, 2017

12.9K

Area of Science:

  • Biomedical Science
  • Gerontology
  • Infectious Disease Epidemiology

Background:

  • Telomeres, critical for cellular aging, are linked to cardiovascular diseases and cancer.
  • Existing research suggests infections may shorten telomeres, but comprehensive evidence is lacking.
  • The relationship between various infection types, severities, and telomere length remains unclear across different populations.

Purpose of the Study:

  • To systematically review and collate evidence on the association between infections and telomere length.
  • To enable comparison of findings across diverse studies and populations.
  • To inform future research directions in cellular aging and infectious diseases.

Main Methods:

  • Comprehensive literature search across multiple databases (MEDLINE, EMBASE, Web of Science, Scopus, Global Health, Cochrane Library) and grey literature.
  • Inclusion of all study types, geographical locations, infection types, and outcome measurement methods.
  • Independent study selection, data extraction, and risk of bias assessment using ROB2 and ROBINS-E tools, with quality appraisal via GRADE criteria.

Main Results:

  • Data synthesis will involve meta-analysis if homogeneity is sufficient, or a narrative synthesis grouped by exposure and study design.
  • Heterogeneity will be evaluated concerning study design, exposure, and outcome measurement.
  • Results will be presented to allow for comparison and identification of trends.

Conclusions:

  • This systematic review will provide a comprehensive overview of the association between infections and telomere length.
  • Findings will clarify the impact of different infections and severities on cellular aging markers.
  • The study aims to guide future research and clinical understanding of infection-related aging processes.