The molecular characteristics of recurrent/metastatic HPV-positive head and neck squamous cell carcinoma: A systematic review of the literature
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View abstract on PubMed
Summary
This summary is machine-generated.Recurrent/metastatic HPV-positive HNSCC shows distinct molecular profiles, including TP53 mutations. Circulating HPV DNA (ctHPVDNA) shows promise for monitoring recurrence and treatment response in these patients.
Area Of Science
- Oncology
- Molecular Biology
- Genetics
Background
- Approximately 17% of human papillomavirus (HPV)-positive head and neck squamous cell carcinoma (HNSCC) patients experience recurrence.
- Recurrent or metastatic disease in HPV-positive HNSCC is often considered incurable.
- Understanding the molecular landscape is crucial for developing effective treatments.
Purpose Of The Study
- To provide an overview of the molecular landscape of recurrent/metastatic HPV-positive HNSCC.
- To identify novel molecular biomarkers for this patient subset.
- To review emerging treatment options.
Main Methods
- A critical qualitative systematic literature review was conducted.
- Searched for studies on molecular characteristics, biomarkers, and treatments for recurrent/metastatic HPV-positive HNSCC.
- Data extraction and quality assessment performed by three independent assessors, with final search in February 2023.
Main Results
- Recurrent/metastatic HPV-positive HNSCC exhibits higher TP53 mutation rates and genomic similarity to HPV-negative HNSCC.
- Circulating tumor HPV DNA (ctHPVDNA) shows promise as a biomarker for monitoring treatment response and recurrence.
- Emerging targeted therapies (e.g., EGFR inhibitors) and combination immunotherapies are under investigation.
Conclusions
- Recurrent/metastatic HPV-positive HNSCC has distinct molecular profiles.
- ctHPVDNA testing holds clinical potential for routine practice in monitoring.
- Further controlled, longitudinal studies are needed to identify additional targets and validate novel biomarkers.
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