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Association between lipoprotein(a) and cardiovascular disease in patients undergoing coronary angiography
Azhi ShaMa1, Chunmei Xu1, Yingying Huang1
1Department of Cardiology, Daping Hospital, The Third Military Medical University (Army Medical University), Chongqing, China.
Insights
Elevated lipoprotein(a) is linked to higher risks of high cholesterol, high LDL-c, and premature coronary artery disease (CAD). This study clarifies its association with cardiovascular disease in patients undergoing angiography.
Area of Science:
- Cardiology
- Lipidology
- Genetics
Background:
- Lipoprotein(a) [Lp(a)] is a recognized risk factor for cardiovascular disease (CVD).
- Previous studies on the association between Lp(a) and CVD have yielded controversial results.
- Understanding Lp(a)'s role in CVD is crucial for risk stratification and management.
Purpose of the Study:
- To investigate the association between elevated lipoprotein(a) and cardiovascular disease.
- To analyze the relationship in patients undergoing coronary angiography.
- To clarify controversial findings regarding Lp(a) and CVD risk.
Main Methods:
- Retrospective study design.
- Inclusion of patients hospitalized for coronary angiography.
- Multivariable hierarchical logistic regression analysis to assess associations.
Main Results:
- Elevated lipoprotein(a) significantly increases the risk of high total cholesterol and high low-density lipoprotein cholesterol (LDL-c).
- Elevated lipoprotein(a) is associated with an increased risk of diabetes and premature coronary artery disease (CAD).
- Elevated lipoprotein(a) correlates with increased incidence and severity of CAD, including multivessel lesions and need for percutaneous coronary intervention (PCI).
Conclusions:
- Elevated lipoprotein(a) is not significantly associated with hypertension or obesity.
- Elevated lipoprotein(a) is a risk factor for dyslipidemia (high total cholesterol, high LDL-c) and premature CAD.
- Elevated lipoprotein(a) contributes to the occurrence and severity of coronary heart disease.
Objective:
Many previous studies reported the relationship between lipoprotein(a) and cardiovascular disease, but the conclusions were controversial. The aim of our study was to retrospectively investigate the association between lipoprotein(a) and cardiovascular disease in patients undergoing coronary angiography.
Methods:
We collected and compared clinical information of patients hospitalized for coronary angiography. Multivariable hierarchical logistic regression was used to evaluate the association between lipoprotein(a) and cardiovascular disease in patients undergoing coronary angiography.
Results:
There were no significant differences in gender, hypertension, APOA1, smoking, hyperuricemia, obesity, acute myocardial infarction (AMI), cardiac insufficiency, family history of diabetes, or family history of hyperlipidemia among the four groups of lipoprotein(a). Elevated lipoprotein(a) does not increase the risk of hypertriglyceridemia, while elevated lipoprotein(a) increases the risk of high total cholesterol and high low-density lipoprotein cholesterol (LDL-c). Elevated lipoprotein(a) increases the risk of diabetes and premature coronary artery disease (CAD). Elevated lipoprotein(a) increases the incidence of CAD, multivessel lesions, and percutaneous coronary intervention (PCI). Multivariate logistic regression analysis further showed that elevated lipoprotein(a) increases the incidence of high total cholesterol, high LDL‑c, diabetes, CAD, premature CAD, multivessel lesions, and PCI.
Conclusion:
The findings indicated that elevated lipoprotein(a) had no obvious relationship with hypertension and obesity. Elevated lipoprotein(a) increases the risk of high total cholesterol, high LDL‑c, and premature CAD, and increases the occurrence and severity of coronary heart disease.
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