Systolic blood pressure status modifies the associations between the triglyceride-glucose index and incident...

Area of Science:

• Cardiology
• Metabolic Syndrome
• Public Health

Background:

• The triglyceride-glucose (TyG) index and blood pressure (BP) are established risk factors for cardiovascular disease (CVD).
• The influence of BP status on the TyG index-CVD association is not fully understood.
• This study examines the TyG index and incident CVD in Chinese adults, considering BP variations.

Purpose of the Study:

• To investigate the relationship between the TyG index and incident CVD in Chinese middle-aged and elderly adults.
• To explore how different blood pressure statuses modify the association between the TyG index and CVD risk.
• To assess the mediating role of systolic blood pressure (SBP) in the TyG index-CVD link.

Main Methods:

• 6558 participants from the China Health and Retirement Longitudinal Study without prevalent CVD were analyzed.
• Participants were stratified by SBP levels (<120mmHg, 120–129mmHg, ≥130mmHg).
• Cox regression and restricted cubic splines were used to assess associations between the TyG index and CVD outcomes.

Main Results:

• A higher TyG index was associated with increased incident CVD risk (HR per 1-SD: 1.19; highest vs. lowest quartile: HR 1.54).
• Systolic blood pressure significantly modified the TyG index-CVD association, with higher risks observed at lower SBP levels (<130mmHg).
• SBP partially mediated the association between the TyG index and CVD risk.

Conclusions:

• Blood pressure status, particularly SBP, modifies the association between the TyG index and CVD risk.
• Higher risks of CVD associated with the TyG index were more pronounced in individuals with SBP <130mmHg.
• Early screening of the TyG index is crucial for identifying individuals at risk for hypertension and subsequent CVD.