Related Experiment Video
Updated: Jun 28, 2025
14:39
Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
Published on: November 4, 2010
31.9K
Barriers to clinical remission in severe asthma
1Pulmonology Department, Coimbra Hospital and University Centre, Praceta Prof. Mota Pinto, Coimbra, 3004-561, Portugal.
Respiratory Research
|April 24, 2024
Summary
Achieving clinical remission in severe asthma is a realistic goal for some patients, focusing on symptom control and reduced oral corticosteroid use. Overcoming barriers like late intervention and comorbidities is key for successful severe asthma management.
Area of Science:
- Pulmonology
- Immunology
- Clinical Medicine
Background:
- Severe asthma presents significant risks, including exacerbations, reduced lung function, and mortality.
- Monoclonal antibody therapies targeting inflammation pathways have shifted focus towards remission as a treatment goal.
Purpose of the Study:
- To review current definitions of asthma remission.
- To identify barriers to achieving remission in severe asthma.
- To propose criteria for clinical remission in severe asthma.
Main Methods:
- Literature review of current definitions and barriers to asthma remission.
- Analysis of factors influencing remission achievement in severe asthma patients.
- Discussion of unmet needs and future directions for remission criteria.
Main Results:
- No unified definition of asthma remission exists.
- Clinical remission requires sustained symptom control, no oral corticosteroids, no exacerbations, and stable lung function.
- Barriers include late intervention, irreversible airway changes, infections, comorbidities, and behavioral factors.
Conclusions:
- Clinical remission is achievable in a subset of severe asthma patients with targeted therapies.
- Addressing unmet needs, phenotyping exacerbations, and managing comorbidities are crucial.
- An international consensus on remission criteria is needed for future guidelines.
Related Concept Videos
01:24Asthma-III: Symptoms and Complications
2.5K
Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma
Classification of Asthma
2.5K
01:20Asthma: Pathogenesis and Management
390
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
390
01:25Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs
279
Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
279
01:20COPD: Pathogenesis and Clinical Features
265
Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
265
01:26COPD: Management Using Bronchodilators and Corticosteroids
198
Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
198
01:17Drugs Used in Lower Respiratory Disorders: Overview
424
Lower respiratory tract disorders present challenges that often require skilled and nuanced approaches for effective management. Common ailments, such as asthma and chronic obstructive pulmonary disease (COPD), have prompted the development of intricate treatment strategies involving bronchodilators and anti-inflammatory drugs, each tailored to ease breathing and revitalize the lungs.
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
424