The association between albumin-corrected calcium and prognosis in patients with cardiac arrest: a retrospective...

Area of Science:

• Cardiology
• Critical Care Medicine
• Clinical Chemistry

Background:

• Cardiac arrest (CA) presents a significant global health challenge with high mortality rates.
• Early and accurate prognosis determination is crucial for managing CA patients.
• The relationship between albumin-corrected calcium (ACC) and CA patient outcomes requires further investigation.

Purpose of the Study:

• To investigate the correlation between albumin-corrected calcium (ACC) levels and the prognosis of patients following cardiac arrest (CA).
• To identify potential cut-off values of ACC associated with mortality risk in CA patients.

Main Methods:

• Retrospective analysis of the Medical Information Mart for Intensive Care IV database.
• Categorization of patients into low, moderate, and high ACC groups based on Restricted Cubic Spline (RCS) analysis cut-off values (8.86 and 10.32).
• Application of Least Absolute Shrinkage and Selection Operator (LASSO) regression, Inverse Probability Treatment Weighting (IPTW), Kaplan-Meier curves, and Cox regression analyses to assess mortality risk.

Main Results:

• RCS analysis revealed a non-linear relationship between ACC and 90-day/360-day mortality.
• Both low ( < 8.86) and high ( > 10.32) ACC groups were identified as independent risk factors for 90-day and 360-day all-cause mortality.
• Kaplan-Meier curves showed significantly lower cumulative survival rates in the low and high ACC groups compared to the moderate ACC group.

Conclusions:

• Elevated or reduced levels of albumin-corrected calcium (ACC) are independently associated with increased 90-day and 360-day mortality in cardiac arrest patients.
• Clinicians should pay close attention to both low and high ACC levels in cardiac arrest patients for risk stratification and management.
• The findings highlight the prognostic significance of ACC in the post-cardiac arrest setting.