Association of Red Cell Distribution Width and Mean Platelet Volume With Disease Activity in Rheumatoid Arthritis...

Area of Science:

• Rheumatology
• Hematology
• Clinical Diagnostics

Background:

• Rheumatoid arthritis (RA) is a chronic systemic inflammatory disorder primarily affecting synovial joints.
• RA leads to significant disability, increased mortality, and economic burdens.
• Identifying reliable markers for RA disease activity is crucial for effective management.

Purpose of the Study:

• To investigate the association between red cell distribution width (RDW) and mean platelet volume (MPV) with disease activity in rheumatoid arthritis patients.
• To evaluate the potential of RDW and MPV as simple tools for assessing RA disease activity.

Main Methods:

• A retrospective study of 100 RA patients diagnosed according to ACR/EULAR 2010 criteria.
• Collected data included patient demographics, clinical history, laboratory results (including RDW and MPV), and disease activity assessed by DAS 28-ESR.
• Linear regression analysis was used to determine the relationship between RDW, MPV, and DAS 28-ESR.

Main Results:

• A strong positive correlation was found between RDW and DAS 28-ESR (r=0.653, p<0.001).
• A moderate positive correlation was observed between MPV and DAS 28-ESR (r=0.366, p<0.001).
• 45% of patients exhibited high disease activity, 34% moderate, 9% low, and 12% were in remission.

Conclusions:

• Both RDW and MPV show a positive correlation with disease activity in RA patients.
• These hematological parameters can serve as accessible and simple indicators for assessing RA disease activity.
• RDW and MPV may aid in guiding treatment decisions for rheumatoid arthritis.